This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient- Oriented Research (K24) to Dr. Kristine Yaffe. The overarching aims of this K24 renewal application are three-fold: 1) To perform rigorous patient-based research studies in a new direction aimed at the identification of the predictors of cognitive aging and structural brain integrity across the lifecourse among biracial adults, 2) To use the applicant's research as a platform for the mentorship of patient-oriented researchers in the epidemiology of cognitive aging and 3) To enable the applicant to pursue new research directions and to continue to support her development as an internationally recognized mentor for trainees from a wide range of disciplines interested in cognitive aging. During the first 5 years of support provided by the K24 award, Dr. Yaffe has been both a very productive mentor and independently funded investigator. During this period, she has obtained eight patient-oriented research grants (3 R01s, 2 Project Cores on Program Projects from NIH, an Investigator-Initiated Research Grant from the Alzheimer's Association, a Department of Defense grant and an American Health Foundation grant). Over the initial K24 project period from 2007 to 2012, Dr. Yaffe has served as primary or secondary mentor to 19 trainees in a wide range of disciplines and at various levels of training. Dr. Yaffe's long-term goals are to become an international leader in aging research, to contribute substantially to our understanding and approaches to the treatment and prevention of cognitive impairment and to mentor the "next generation" of investigators interested in the epidemiology of cognitive aging. This one-time renewal of a mid-career development award will help her to reach these goals.

Public Health Relevance

The identification of who is at risk for cognitive impairment associated with aging remains one of the most important goals of our time. By increasing our understanding of cognitive function in midlife and identifying earlier risk factors extending from early adulthood, it may be possible to intervene to prevent dementia and maintain healthy brain aging. In addition, knowledge of the lifecourse antecedents, including the timing and cumulative risk of exposure, of cognitive aging could inform the nature of these interventions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J1))
Program Officer
Wagster, Molly V
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Mayeda, Elizabeth R; Haan, Mary N; Neuhaus, John et al. (2014) Type 2 diabetes and cognitive decline over 14 years in middle-aged African Americans and whites: the ARIC Brain MRI Study. Neuroepidemiology 43:220-7
Hoang, Tina D; Byers, Amy L; Barnes, Deborah E et al. (2014) Alcohol consumption patterns and cognitive impairment in older women. Am J Geriatr Psychiatry 22:1663-7
Gardner, Raquel C; Yaffe, Kristine (2014) Traumatic brain injury may increase risk of young onset dementia. Ann Neurol 75:339-41
Meziab, Omar; Kirby, Katharine A; Williams, Brie et al. (2014) Prisoner of war status, posttraumatic stress disorder, and dementia in older veterans. Alzheimers Dement 10:S236-41
Barnes, Deborah E; Cenzer, Irena S; Yaffe, Kristine et al. (2014) A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease. Alzheimers Dement 10:646-55
Zeki Al Hazzouri, Adina; Vittinghoff, Eric; Byers, Amy et al. (2014) Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women. J Gerontol A Biol Sci Med Sci 69:595-601
Kaup, Allison R; Simonsick, Eleanor M; Harris, Tamara B et al. (2014) Older adults with limited literacy are at increased risk for likely dementia. J Gerontol A Biol Sci Med Sci 69:900-6
Byers, Amy L; Covinsky, Kenneth E; Neylan, Thomas C et al. (2014) Chronicity of posttraumatic stress disorder and risk of disability in older persons. JAMA Psychiatry 71:540-6
Yokoyama, Jennifer S; Evans, Daniel S; Coppola, Giovanni et al. (2014) Genetic modifiers of cognitive maintenance among older adults. Hum Brain Mapp 35:4556-65
Spira, Adam P; Stone, Katie L; Rebok, George W et al. (2014) Sleep-disordered breathing and functional decline in older women. J Am Geriatr Soc 62:2040-6

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