This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient- Oriented Research (K24) to Dr. Kristine Yaffe. The overarching aims of this K24 renewal application are three-fold: 1) To perform rigorous patient-based research studies in a new direction aimed at the identification of the predictors of cognitive aging and structural brain integrity across the lifecourse among biracial adults, 2) To use the applicant's research as a platform for the mentorship of patient-oriented researchers in the epidemiology of cognitive aging and 3) To enable the applicant to pursue new research directions and to continue to support her development as an internationally recognized mentor for trainees from a wide range of disciplines interested in cognitive aging. During the first 5 years of support provided by the K24 award, Dr. Yaffe has been both a very productive mentor and independently funded investigator. During this period, she has obtained eight patient-oriented research grants (3 R01s, 2 Project Cores on Program Projects from NIH, an Investigator-Initiated Research Grant from the Alzheimer's Association, a Department of Defense grant and an American Health Foundation grant). Over the initial K24 project period from 2007 to 2012, Dr. Yaffe has served as primary or secondary mentor to 19 trainees in a wide range of disciplines and at various levels of training. Dr. Yaffe's long-term goals are to become an international leader in aging research, to contribute substantially to our understanding and approaches to the treatment and prevention of cognitive impairment and to mentor the """"""""next generation"""""""" of investigators interested in the epidemiology of cognitive aging. This one-time renewal of a mid-career development award will help her to reach these goals.
The identification of who is at risk for cognitive impairment associated with aging remains one of the most important goals of our time. By increasing our understanding of cognitive function in midlife and identifying earlier risk factors extending from early adulthood, it may be possible to intervene to prevent dementia and maintain healthy brain aging. In addition, knowledge of the lifecourse antecedents, including the timing and cumulative risk of exposure, of cognitive aging could inform the nature of these interventions.
|Cleret de Langavant, Laurent; Bayen, Eleonore; Yaffe, Kristine (2018) Unsupervised Machine Learning to Identify High Likelihood of Dementia in Population-Based Surveys: Development and Validation Study. J Med Internet Res 20:e10493|
|Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165|
|Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901|
|Kaup, Allison R; Xia, Feng; Launer, Lenore J et al. (2018) Occupational cognitive complexity in earlier adulthood is associated with brain structure and cognitive health in midlife: The CARDIA study. Neuropsychology 32:895-905|
|Ward, Michael E; Gelfand, Jeffrey M; Lui, Li-Yung et al. (2018) Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol 83:730-738|
|Leng, Yue; Goldman, Samuel M; Cawthon, Peggy M et al. (2018) Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol 47:1679-1686|
|Kaup, Allison R; Peltz, Carrie; Kenney, Kimbra et al. (2017) Neuropsychological Profile of Lifetime Traumatic Brain Injury in Older Veterans. J Int Neuropsychol Soc 23:56-64|
|Leng, Yue; McEvoy, Claire T; Allen, Isabel E et al. (2017) Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis. JAMA Neurol 74:1237-1245|
|Gardner, Raquel C; Langa, Kenneth M; Yaffe, Kristine (2017) Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study. PLoS Med 14:e1002246|
|Peltz, Carrie B; Gardner, Raquel C; Kenney, Kimbra et al. (2017) Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury. J Head Trauma Rehabil 32:E8-E15|
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