This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is intended to promote mentoring activities and career development focused on the immunology of aging. Notably, no other currently funded K24 at the NIA is devoted to translational immunology. The PI, Dr. Shaw, is Associate Professor of Medicine at the Yale School of Medicine;he is trained in Internal Medicine and Infectious Disease, and in addition has a Ph.D. in Genetics and is a trained immunologist. Dr. Shaw is recognized as an authority on the aging of the human immune system;his lab has a special interest in aging of the innate immune system, and has carried out the largest and most comprehensive studies to date of the consequences of aging on human Toll-like Receptor (TLR) function. These studies defined features of immunosenescence in the innate immune system, and also demonstrated the linkage between TLR function and adaptive immune responses such as antibody response to influenza vaccine. Although Dr. Shaw has mentored several young investigators who remain in academic research positions, at present his mentoring activities must compete with administrative, clinical and research commitments. In this regard, he is at an ideal point in his career to expand his mentoring activities through the K24 mechanism. Dr. Shaw has recently begun two newly funded projects in patient- oriented research-in the first, he serves as Project Leader for an NIAID contract focusing on understanding age-associated alterations in innate immune pattern recognition receptor function. In the second, he is the PI of an R01 within a U19 Center Grant that is part of the NIH Human Immunophenotyping Consortium. This project will elucidate immunologic and gene expression signatures of influenza vaccine response, and will determine how aging and frailty affect these signatures. These two initiatives form the platform for development of a mentoring and career development plan directed to developing new investigators studying the immunology of aging. In addition, two additional projects would be directly supported by this application: the first, a pilot study of innate immune function in young and older individuals with HIV infection. The second exploratory project leverages an ongoing NIA-sponsored clinical trial at Yale of a multicomponent intervention of upright feeding position and enhanced oral care on nursing home pneumonia prevention. We will evaluate the relationship between innate immune function and results of an ongoing substudy on alterations in oral microbiome composition with enhanced oral care. This research platform will be supported by career development activities that include tutorials in clinical geriatrics, computational biology, and gerontologic biostatistic. Taken together, this program will further enhance the PI's role as a mentor to the next generation of investigators who will advance our understanding of human immunology in the context of aging.

Public Health Relevance

This application is designed to allow Dr. Albert Shaw, an Associate Professor of Medicine at the Yale School of Medicine, to enhance his ability to mentor young investigators, obtain training in clinical and scientific areas that will improve his researc and mentoring capabilities, and develop new research directions in addition to ongoing funded projects. Dr. Shaw's research focuses on understanding how aging affects the immune system's ability to respond to disease-causing organisms or protective vaccination. Because no K24 awards from the National Institute on Aging are currently focused on this area, this proposal will allow Dr. Shaw to help train the next generation of investigators who will make important contributions to this vital topic.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AG042489-03
Application #
8699112
Study Section
Neuroscience of Aging Review Committee (NIA)
Program Officer
Fuldner, Rebecca A
Project Start
2012-08-01
Project End
2017-04-30
Budget Start
2014-08-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Pillai, Padmini S; Molony, Ryan D; Martinod, Kimberly et al. (2016) Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 352:463-6
Mohanty, Subhasis; Joshi, Samit R; Ueda, Ikuyo et al. (2015) Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis 211:1174-84
Thakar, Juilee; Mohanty, Subhasis; West, A Phillip et al. (2015) Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY) 7:38-52
Howell, Benjamin A; Azar, Marwan M; Landry, Marie L et al. (2015) Toscana virus encephalitis in a traveler returning to the United States. J Clin Microbiol 53:1445-7
Shin, Min Sun; You, Sungyong; Kang, Youna et al. (2015) DNA Methylation Regulates the Differential Expression of CX3CR1 on Human IL-7Rαlow and IL-7Rαhigh Effector Memory CD8+ T Cells with Distinct Migratory Capacities to the Fractalkine. J Immunol 195:2861-9
Joshi, Samit R; Mohanty, Subhasis; Shaw, Albert C (2015) Multicolor Digital Flow Cytometry in Human Translational Immunology. Methods Mol Biol 1343:53-64
Walker, Wendy E; Kurscheid, Sebastian; Joshi, Samit et al. (2015) Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. J Virol 89:5502-14
Montgomery, Ruth R; Shaw, Albert C (2015) Paradoxical changes in innate immunity in aging: recent progress and new directions. J Leukoc Biol 98:937-43
Juthani-Mehta, Manisha; Guo, Xiuyang; Shaw, Albert C et al. (2014) Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. J Aging Sci 2:
Zhou, Yang; Peng, Hong; Sun, Huanxing et al. (2014) Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Sci Transl Med 6:240ra76

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