Abstract

Project Description This is a competing renewal application for a K24 Mid-Career Award in Patient-Oriented Research for Joseph M. Vinetz, M.D. of the University of California San Diego. The applicant's original award proposed to provide support for patient oriented research on tropical diseases including malaria and leptospirosis with a particularly emphasis on the mentoring of junior physician-scholar trainees at all levels. These goals were met as demonstrated by publications, new research and training grants to support patient-oriented research and career advancement of mentees including patient-oriented career research awards from the NIH. In the new project period, patient-oriented research projects in malaria, leptospirosis, and brucellosis are proposed as vehicles to mentor junior physician scientists at all levels leveraging funded NIH grants. Substantial emphasis is placed on recruiting a diverse workforce and on formal training in the responsible conduct of research. Research projects will take place in the U.S., Peru and Brazil.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI068903-07
Application #
8338784
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Rao, Malla R
Project Start
2006-03-01
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
7
Fiscal Year
2012
Total Cost
$124,958
Indirect Cost
$9,256

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

White, Sara E; Harvey, Steven A; Meza, Graciela et al. (2018) Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malar J 17:179
Rosas-Aguirre, Angel; Gamboa, Dionicia; Manrique, Paulo et al. (2016) Epidemiology of Plasmodium vivax Malaria in Peru. Am J Trop Med Hyg 95:133-144
Hupalo, Daniel N; Luo, Zunping; Melnikov, Alexandre et al. (2016) Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet 48:953-8
Agampodi, Suneth B; Dahanayaka, Niroshan J; Nöckler, Karsten et al. (2016) Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. Am J Trop Med Hyg 95:531-6
Wunder Jr, Elsio A; Figueira, Claudio P; Santos, Gisele R et al. (2016) Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters. Infect Immun 84:2105-2115
Fouts, Derrick E; Matthias, Michael A; Adhikarla, Haritha et al. (2016) What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis 10:e0004403
Patra, Kailash P; Li, Fengwu; Carter, Darrick et al. (2015) Alga-produced malaria transmission-blocking vaccine candidate Pfs25 formulated with a human use-compatible potent adjuvant induces high-affinity antibodies that block Plasmodium falciparum infection of mosquitoes. Infect Immun 83:1799-808
Chuquiyauri, Raul; Molina, Douglas M; Moss, Eli L et al. (2015) Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection. Am J Trop Med Hyg 93:801-9
Manrique, Paulo; Hoshi, Mari; Fasabi, Manuel et al. (2015) Assessment of an automated capillary system for Plasmodium vivax microsatellite genotyping. Malar J 14:326
Llanos-Chea, Fiorella; Martínez, Dalila; Rosas, Angel et al. (2015) Characteristics of Travel-Related Severe Plasmodium vivax and Plasmodium falciparum Malaria in Individuals Hospitalized at a Tertiary Referral Center in Lima, Peru. Am J Trop Med Hyg 93:1249-53

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