Project Description This is a competing renewal application for a K24 Mid-Career Award in Patient-Oriented Research for Joseph M. Vinetz, M.D. of the University of California San Diego. The applicant's original award proposed to provide support for patient oriented research on tropical diseases including malaria and leptospirosis with a particularly emphasis on the mentoring of junior physician-scholar trainees at all levels. These goals were met as demonstrated by publications, new research and training grants to support patient-oriented research and career advancement of mentees including patient-oriented career research awards from the NIH. In the new project period, patient-oriented research projects in malaria, leptospirosis, and brucellosis are proposed as vehicles to mentor junior physician scientists at all levels leveraging funded NIH grants. Substantial emphasis is placed on recruiting a diverse workforce and on formal training in the responsible conduct of research. Research projects will take place in the U.S., Peru and Brazil.

Agency
National Institute of Health (NIH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI068903-09
Application #
8709975
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Rao, Malla R
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Cannella, Anthony P; Arlehamn, Cecilia S Lindestam; Sidney, John et al. (2014) Brucella melitensis T cell epitope recognition in humans with brucellosis in Peru. Infect Immun 82:124-31
Torres, Katherine J; Villasis, Elizabeth; BendezĂș, Jorge et al. (2014) Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region. Malar J 13:108
Patra, Kailash P; Saito, Mayuko; Atluri, Vidya L et al. (2014) A protein-conjugate approach to develop a monoclonal antibody-based antigen detection test for the diagnosis of human brucellosis. PLoS Negl Trop Dis 8:e2926
Feldman, Kristyn E; Loriaux, Paul M; Saito, Mayuko et al. (2013) Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. PLoS Negl Trop Dis 7:e2424
Agampodi, Suneth B; Moreno, Angelo C; Vinetz, Joseph M et al. (2013) Utility and limitations of direct multi-locus sequence typing on qPCR-positive blood to determine infecting Leptospira strain. Am J Trop Med Hyg 88:184-5
Abeles, Shira R; Chuquiyauri, Raul; Tong, Carlos et al. (2013) Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon. Am J Trop Med Hyg 88:1130-7
Chuquiyauri, Raul; Penataro, Pablo; Brouwer, Kimberly C et al. (2013) Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon. Am J Trop Med Hyg 89:326-38
Chuquiyauri, Raul; Paredes, Maribel; Penataro, Pablo et al. (2012) Socio-demographics and the development of malaria elimination strategies in the low transmission setting. Acta Trop 121:292-302
Agampodi, Suneth B; Matthias, Michael A; Moreno, Angelo C et al. (2012) Utility of quantitative polymerase chain reaction in leptospirosis diagnosis: association of level of leptospiremia and clinical manifestations in Sri Lanka. Clin Infect Dis 54:1249-55
Karris, Maile Young; Litwin, Christine M; Dong, Hong S et al. (2011) Bartonella henselae infection of prosthetic aortic valve associated with colitis. Vector Borne Zoonotic Dis 11:1503-5

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