Immediate Goals: To determine the role of environmental and genetic factors on the development of both bronchiolitis and asthma, with the goal of designing and implementing more effective preventive therapies to reduce the incidence and severity of both infant viral infections and childhood asthma. Career Development Goals: To provide sufficient time for mentoring and research activities. Research Project: Asthma is thought to result from host (genetic) and environment interactions. Viral infections are one important, and modifiable environmental factor that have been established to be important causes of asthma exacerbations in both children and adults;lower respiratory tract infections (LRTI), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants. Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. It is not known whether viral respiratory infections directly contribute to asthma causation or simply identify persons at risk for subsequent wheezing. Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. This proposal uses a combined, parallel clinical and experimental approach to evaluate the contribution of, causality, and mechanism of how viruses contribute to asthma causation and natural history, all relating to the central hypothesis that viruses, as one significant environmental factor, alter the risk for developing asthma, as well as the natural history of prevalent disease. Specific testable questions related to this hypothesis include: 1) the respiratory viral pathogen, environmental factors, and timing of infection during infancy impact the risk of developing childhood asthma;2) lower respiratory viral infection during infancy, and the severity of that infection correlates with an increased risk of childhood asthma;3) allelic variations at genes involved with severity of respiratory viral infection will correlate with a predisposition or resistance to both infant bronchiolitis and childhood asthma.
The aims of the mentored award will be met by allowing the PI to translate her experimental expertise to direct clinical studies of progression and functional outcome of childhood viral illness and asthma, with the next goal to make the transition from risk factor determination to intervention and disease prevention.
|Valet, Robert S; Gebretsadik, Tebeb; Minton, Patricia A et al. (2015) Prevalence and characteristics of medication sharing behavior in a pediatric Medicaid population with asthma. Ann Allergy Asthma Immunol 114:151-3|
|Langley, Emily W; Gebretsadik, Tebeb; Hartert, Tina V et al. (2014) Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations. J Allergy Clin Immunol Pract 2:618-20.e1|
|Bobo, William V; Epstein Jr, Richard A; Hayes, Rachel M et al. (2014) The effect of regulatory advisories on maternal antidepressant prescribing, 1995-2007: an interrupted time series study of 228,876 pregnancies. Arch Womens Ment Health 17:17-26|
|Jackson, Daniel J; Hartert, Tina V; Martinez, Fernando D et al. (2014) Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc 11 Suppl 3:S139-45|
|Vereen, Shanda; Gebretsadik, Tebeb; Hartert, Tina V et al. (2014) Association between breast-feeding and severity of acute viral respiratory tract infection. Pediatr Infect Dis J 33:986-8|
|Arnold, Donald H; Gebretsadik, Tebeb; Hartert, Tina V (2013) Spirometry and PRAM severity score changes during pediatric acute asthma exacerbation treatment in a pediatric emergency department. J Asthma 50:204-8|
|Valet, Robert S; Gebretsadik, Tebeb; Carroll, Kecia N et al. (2013) Increased healthcare resource utilization for acute respiratory illness among Latino infants. J Pediatr 163:1186-91|
|Sloan, Chantel D; Gebretsadik, Tebeb; Wu, Pingsheng et al. (2013) Spatiotemporal patterns of infant bronchiolitis in a Tennessee Medicaid population. Spat Spatiotemporal Epidemiol 6:17-23|
|James, Kristina M; Gebretsadik, Tebeb; Escobar, Gabriel J et al. (2013) Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season. J Allergy Clin Immunol 132:227-9|
|Lemke, Meghan; Hartert, Tina V; Gebretsadik, Tebeb et al. (2013) Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. Ann Allergy Asthma Immunol 110:433-7|
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