The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Anthony Harris, is an infectious disease physician and epidemiologist. During his fourteen years as faculty, he has had more than 125 manuscripts published. Among these manuscripts, he has been first or last author on more than 50. Most of these manuscripts have been focused in the following research areas: antimicrobial resistance, hospital epidemiology, infection control, and epidemiological and statistical methods in the study of antimicrobial resistance. His mentees have had over 450 publications from the time of his mentoring to the present. 101 publications have been mentee/mentor publications. Eighteen of 33 mentees are presently pursuing academic medical careers. In the initial five years of his K24, he successfully completed all proposed aims and mentored six faculty's career development awards. During the K24 period, he had over 46 publications of which 44 involved mentees. His current level of funding includes an NIH R01, an AHRQ R01, a CDC contract that has frequent requests for additional sub-contracts, a co-investigator on an NIH contract and two industry-sponsored research grants. Renewal of this K24 is critical to his desire to continue to mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve his research. He will take additional coursework to help move his research into the areas of cluster-randomized trials, genomic epidemiology, comparative effectiveness research and the study of the microbiome and antibiotic-resistance. The protected time is critical to Dr. Harris achieving these goals;without the K24 renewal, he will have to attend more on the infectious disease service and perform more hospital epidemiology and quality improvement in order to increase reimbursement directed towards his salary.
Antibiotic-resistant bacteria and healthcare-associated infections increase patient morbidity and mortality;thus, they are an important public health concern. The proposed work will mentor young investigators in the emerging areas of antibiotic-resistance, healthcare-associated infections and hospital epidemiology and to continue to evolve research in these areas.
|Rock, Clare; Thom, Kerri A; Harris, Anthony D et al. (2016) A Multicenter Longitudinal Study of Hospital-Onset Bacteremia: Time for a New Quality Outcome Measure? Infect Control Hosp Epidemiol 37:143-8|
|Masnick, Max; Morgan, Daniel J; Sorkin, John D et al. (2016) Lack of Patient Understanding of Hospital-Acquired Infection Data Published on the Centers for Medicare and Medicaid Services Hospital Compare Website. Infect Control Hosp Epidemiol 37:182-7|
|Wallace, Lalena; Daugherty, Sean C; Nagaraj, Sushma et al. (2016) Use of Comparative Genomics To Characterize the Diversity of Acinetobacter baumannii Surveillance Isolates in a Health Care Institution. Antimicrob Agents Chemother 60:5933-41|
|Harris, Anthony D; Jackson, Sarah S; Robinson, Gwen et al. (2016) Pseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes. Infect Control Hosp Epidemiol 37:544-8|
|Pettigrew, Melinda M; Johnson, J Kristie; Harris, Anthony D (2016) The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance. Ann Epidemiol 26:342-7|
|Goodman, Katherine E; Lessler, Justin; Cosgrove, Sara E et al. (2016) A Clinical Decision Tree to Predict Whether a Bacteremic Patient Is Infected With an Extended-Spectrum Î²-Lactamase-Producing Organism. Clin Infect Dis 63:896-903|
|Sarg, Mohamed; Waldrop, Greer E; Beier, Mona A et al. (2016) Impact of Changes in Urine Culture Ordering Practice on Antimicrobial Utilization in Intensive Care Units at an Academic Medical Center. Infect Control Hosp Epidemiol 37:448-54|
|Croft, Lindsay D; Liquori, Michael; Ladd, James et al. (2015) The Effect of Contact Precautions on Frequency of Hospital Adverse Events. Infect Control Hosp Epidemiol 36:1268-74|
|Tamma, Pranita D; Han, Jennifer H; Rock, Clare et al. (2015) Carbapenem therapy is associated with improved survival compared with piperacillin-tazobactam for patients with extended-spectrum Î²-lactamase bacteremia. Clin Infect Dis 60:1319-25|
|Rock, Clare; Harris, Anthony D; Johnson, J Kristie et al. (2015) Infrequent air contamination with Acinetobacter baumannii of air surrounding known colonized or infected patients. Infect Control Hosp Epidemiol 36:830-2|
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