This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases;and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants.
These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

Public Health Relevance

This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a 'world-class'academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI085118-03
Application #
8259507
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Hall, Robert H
Project Start
2010-06-01
Project End
2015-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
3
Fiscal Year
2012
Total Cost
$199,014
Indirect Cost
$14,742
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Staab, Janet F; Neofytos, Dionysios; Rhee, Peter et al. (2014) Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr. Antimicrob Agents Chemother 58:5421-7
Dufresne, Simon F; Marr, Kieren A; Sydnor, Emily et al. (2014) Epidemiology of Candida kefyr in patients with hematologic malignancies. J Clin Microbiol 52:1830-7
Neofytos, Dionissios; Lu, Kit; Hatfield-Seung, Amy et al. (2013) Epidemiology, outcomes, and risk factors of invasive fungal infections in adult patients with acute myelogenous leukemia after induction chemotherapy. Diagn Microbiol Infect Dis 75:144-9
Lyons, Jennifer L; Roos, Karen L; Marr, Kieren A et al. (2013) Cerebrospinal fluid (1,3)-?-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis. J Clin Microbiol 51:1285-7
Shoham, Shmuel (2013) Cytomegalovirus: prophylaxis, preemption, or "wait and watch". Liver Transpl 19:108
Shoham, Shmuel; Shah, Pali D (2013) Impact of multidrug-resistant organisms on patients considered for lung transplantation. Infect Dis Clin North Am 27:343-58
Alonso, Carolyn D; Dufresne, Simon F; Hanna, David B et al. (2013) Clostridium difficile infection after adult autologous stem cell transplantation: a multicenter study of epidemiology and risk factors. Biol Blood Marrow Transplant 19:1502-8
Alonso, Carolyn D; Marr, Kieren A (2013) Clostridium difficile infection among hematopoietic stem cell transplant recipients: beyond colitis. Curr Opin Infect Dis 26:326-31
Durand, Christine M; Marr, Kieren A; Arnold, Christina A et al. (2013) Detection of cytomegalovirus DNA in plasma as an adjunct diagnostic for gastrointestinal tract disease in kidney and liver transplant recipients. Clin Infect Dis 57:1550-9
Shoham, Shmuel (2013) Emerging fungal infections in solid organ transplant recipients. Infect Dis Clin North Am 27:305-16

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