This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases;and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants.
These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

Public Health Relevance

This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a world-class academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI085118-04
Application #
8461505
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Hall, Robert H
Project Start
2010-06-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$199,014
Indirect Cost
$14,742
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Avery, Robin K; Arav-Boger, Ravit; Marr, Kieren A et al. (2016) Outcomes in Transplant Recipients Treated With Foscarnet for Ganciclovir-Resistant or Refractory Cytomegalovirus Infection. Transplantation 100:e74-80
Neofytos, D; Ostrander, D; Shoham, S et al. (2015) Voriconazole therapeutic drug monitoring: results of a prematurely discontinued randomized multicenter trial. Transpl Infect Dis 17:831-7
Franco-Paredes, Carlos; Womack, Tanea; Bohlmeyer, Teri et al. (2015) Management of Cryptococcus gattii meningoencephalitis. Lancet Infect Dis 15:348-55
Shoham, S; Ostrander, D; Marr, K (2015) Posaconazole liquid suspension in solid organ transplant recipients previously treated with voriconazole. Transpl Infect Dis 17:493-6
Shah, Neel B; Shoham, Shmuel; Nayak, Seema (2015) Cryptococcus neoformans prosthetic joint infection: case report and review of the literature. Mycopathologia 179:275-8
Marr, Kieren A; Schlamm, Haran T; Herbrecht, Raoul et al. (2015) Combination antifungal therapy for invasive aspergillosis: a randomized trial. Ann Intern Med 162:81-9
Staab, Janet F; Neofytos, Dionysios; Rhee, Peter et al. (2014) Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr. Antimicrob Agents Chemother 58:5421-7
Dufresne, Simon F; Marr, Kieren A; Sydnor, Emily et al. (2014) Epidemiology of Candida kefyr in patients with hematologic malignancies. J Clin Microbiol 52:1830-7
Shoham, Shmuel (2013) Cytomegalovirus: prophylaxis, preemption, or "wait and watch". Liver Transpl 19:108
Shoham, Shmuel; Shah, Pali D (2013) Impact of multidrug-resistant organisms on patients considered for lung transplantation. Infect Dis Clin North Am 27:343-58

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