The candidate, Dr. Carey Farquhar, proposes a mentoring program in global HIV/AIDS research for pre- and post-doctoral fellows and students pursuing a career in patient-oriented research at the University of Washington (UW) and in Kenya. Dr. Farquhar has a strong record in mentoring, having mentored more than 25 trainees since completing infectious disease fellowship in June 2002. She currently mentors 2 UW infectious disease fellows,1 UW post- doctoral fellow, 2 Kenyan post-doctoral fellows, and chairs 3 doctoral committees for students in the UW Department of Epidemiology, all of whom are actively involved in clinical or molecular epidemiology projects based in Nairobi. She has several ongoing studies with federal and non- federal funding that will provide opportunities for her trainees and through this award anticipates expanding her research agenda to include new studies focused on immune responses to common childhood infectious pathogens. The proposed research projects build on past collaborative work in mother-to-child HIV transmission, passive immunity and vaccination again common infant pathogens, particularly measles, a leading cause of infant morbidity and mortality in sub-Saharan Africa. The first project, "Impact of Highly Active Antiretroviral Therapy during Pregnancy and Breastfeeding on Passive Transfer of Antibodies against Measles, Rotavirus, and Pneumococcus," utilizes data from an existing randomized clinical trial and investigates non-HIV causes of morbidity and mortality in resource-limited settings. The second project, "Sustainable Responses to Measles Vaccination among HIV-1-infected Children on HAART," addresses an important gap in knowledge regarding responses to measles re-vaccination among Kenyan children on HAART. Dr. Farquhar proposes to use the K24 award to improve her research and mentoring skills, with special emphasis on building translational research capacity through work with the UW Institute for Translational Health Science and on training infectious disease fellows in Pediatrics and Medicine. The University of Washington is an ideal setting for her proposed mentoring program due to its rich and varied resources in global health and HIV/AIDS research and the increasing number of highly qualified applicants interested in conducting clinical research in a resource- limited setting. Without an understanding of protection against non-HIV pathogens, many children who avoid HIV-1 infection or are successfully treated with HAART will succumb to vaccine-preventable infections, such as measles. These two studies address problems of major public health importance and will allow Dr. Farquhar to continue mentoring US and Kenyan trainees as she broadens her research agenda.

Public Health Relevance

Without an understanding of protection against non-HIV pathogens, many children who avoid HIV-1 infection or are successfully treated with HAART will succumb to vaccine-preventable infections, such as measles. These two studies address problems of major public health importance and will allow Dr. Farquhar to continue mentoring US and Kenyan trainees as she broadens her research agenda.

Agency
National Institute of Health (NIH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI087399-05
Application #
8691662
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Miller, Judith A
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Soh, Jason; Rositch, Anne F; Koutsky, Laura et al. (2014) Individual and partner risk factors associated with abnormal cervical cytology among women in HIV-discordant relationships. Int J STD AIDS 25:315-24
Slyker, Jennifer; Farquhar, Carey; Atkinson, Claire et al. (2014) Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection. Clin Infect Dis 58:564-72
Slyker, Jennifer A; Patterson, Janna; Ambler, Gwen et al. (2014) Correlates and outcomes of preterm birth, low birth weight, and small for gestational age in HIV-exposed uninfected infants. BMC Pregnancy Childbirth 14:7
Newman, Laura P; Njoroge, Anne; Ben-Youssef, Leila et al. (2014) Measles seropositivity in HIV-infected Kenyan children on antiretroviral therapy. Pediatr Infect Dis J 33:843-5
Merkel, Michele; Ben-Youssef, Leila; Newman, Laura P et al. (2014) Seroprevalence of measles IgG among HIV-1-infected and uninfected Kenyan adults. Int J Infect Dis 19:103-5
Roxby, Alison C; Atkinson, Claire; Asbjörnsdóttir, Kristjana et al. (2014) Maternal valacyclovir and infant cytomegalovirus acquisition: a randomized controlled trial among HIV-infected women. PLoS One 9:e87855
Kahn, Talia R; Desmond, Michelle; Rao, Deepa et al. (2013) Delayed initiation of antiretroviral therapy among HIV-discordant couples in Kenya. AIDS Care 25:265-72
Roxby, Alison C; Liu, Amy Y; Drake, Alison L et al. (2013) Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir. AIDS Res Hum Retroviruses 29:94-8
Mujugira, Andrew; Heffron, Renee; Celum, Connie et al. (2013) Fertility intentions and interest in early antiretroviral therapy among East African HIV-1-infected individuals in serodiscordant partnerships. J Acquir Immune Defic Syndr 63:e33-5
Roxby, Alison C; Matemo, Daniel; Drake, Alison L et al. (2013) Pregnant women and disclosure to sexual partners after testing HIV-1-seropositive during antenatal care. AIDS Patient Care STDS 27:33-7

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