My long-term career goal is to develop a global health research-training program for United States and international physician-scientists with a focus on HIV and tuberculosis. The goals of this K24 proposal are to train physician scientists and outstanding pre-doctoral students through the conduct of research primarily in Haiti, and also in Tanzania and to conduct a new research project on HIV induced chronic inflammation in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti and Tanzania, which have on-site Weill Cornell faculty, advanced telecommunications, and outstanding environments for research training. Physician-scientists may pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College. The research strategy includes a new research project in Haiti to be supported by the K24 award on HIV induced chronic inflammation (AIM 1), currently funded projects in Haiti (AIMS 2 - 5), and a currently funded project at a new research site in Mwanza, Tanzania (AIM 6). The common theme is that all the projects have patient-oriented research on AIDS and TB as the focus and will serve as training vehicles for research trainees. The projects include the following: 1. Chronic inflammation as a consequence of delayed ART: biomarkers and sequelae 2. Cervical cancer in HIV infected women: role of prostaglandin E2 3. Tuberculosis biomarkers for diagnosis and for monitoring therapy 4. HIV vaccine and ART clinical trials 5. Multidrug resistant tuberculosis surveillance and control 6. Female urogenital schistosomiasis and HIV interactions Five of the projects involve long-term study of cohorts in Haiti, and the sixth a cohot in Tanzania. There are both clinical and laboratory aspects to all studies which offer trainees broad experience. Trainees learn through the conduct of an independent project and the opportunity to interact with colleagues working on studies other than their own.

Public Health Relevance

The K24 proposal will support Dr Daniel Fitzgerald to train physician scientists and outstanding pre-doctoral students through the conduct of HIV and tuberculosis research primarily in Haiti, and also in Tanzania and to conduct a new project on HIV induced chronic inflammation in Haiti. Physician-scientist trainees may also pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI098627-02
Application #
8449115
Study Section
AIDS Clinical Studies and Epidemiology Study Section (ACE)
Program Officer
Huebner, Robin E
Project Start
2012-04-01
Project End
2017-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
2
Fiscal Year
2013
Total Cost
$175,433
Indirect Cost
$12,995
Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Peck, Robert N; Wang, Richard J; Mtui, Graham et al. (2016) Linkage to Primary Care and Survival After Hospital Discharge for HIV-Infected Adults in Tanzania: A Prospective Cohort Study. J Acquir Immune Defic Syndr 73:522-530
Kingery, Justin R; Alfred, Yona; Smart, Luke R et al. (2016) Short-term and long-term cardiovascular risk, metabolic syndrome and HIV in Tanzania. Heart 102:1200-5
Pierre, Samuel; Jannat-Khah, Deanna; Fitzgerald, Daniel W et al. (2016) 10-Year Survival of Patients with AIDS Receiving Antiretroviral Therapy in Haiti. N Engl J Med 374:397-8
Batavia, Ashita S; Secours, Rode; Espinosa, Patrice et al. (2016) Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial. PLoS One 11:e0150656
Peck, Robert N; Wang, Richard J; Mtui, Graham et al. (2016) Linkage to primary care and survival after hospital discharge for HIV-infected adults in Tanzania: a prospective cohort study. J Acquir Immune Defic Syndr :
Ocheretina, Oksana; Byrt, Erin; Mabou, Marie-Marcelle et al. (2016) False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load. Diagn Microbiol Infect Dis 85:53-5
Esperance, Morgan C; Koenig, Serena P; Guiteau, Colette et al. (2016) A successful model for rapid triage of symptomatic patients at an HIV testing site in Haiti. Int Health 8:96-100
Maginga, John; Guerrero, Mariana; Koh, Eileen et al. (2016) Hypertension Control and Its Correlates Among Adults Attending a Hypertension Clinic in Tanzania. J Clin Hypertens (Greenwich) 18:207-16
Kapoor, Shikha W; Magambo, Kinanga A; Kalluvya, Samuel E et al. (2015) Six-month outcomes of HIV-infected patients given short-course fluconazole therapy for asymptomatic cryptococcal antigenemia. AIDS 29:2473-8
Collins, S E; Jean Juste, M A; Koenig, S P et al. (2015) CD4 deficit and tuberculosis risk persist with delayed antiretroviral therapy: 5-year data from CIPRA HT-001. Int J Tuberc Lung Dis 19:50-7

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