This K24 application provides 33% salary support to Dr. Hauser to allow him to mentor MD or MD/PhD fellows, improve his mentorship skills, and pursue patient-oriented research in the area of hospital-acquired bacterial pathogens. In particular, this award will allow him to continue current research on the role of Pseudomonas aeruginosa type III secretion in the progression of pneumonia. Bacterial type III secretion systems form needle-like structures that inject toxins called """"""""effector proteins"""""""" directly into the cytosol of host cells. The goal of this study is to determine how P. aeruginosa wields effector proteins in vivo to cause severe pneumonia. The focus will be on interactions between the host innate immune system and effector proteins. The relevance of these findings will be confirmed in human patients infected with P. aeruginosa. In addition to expediting current research, this award will allow Dr. Hauser to expand his research into a new area. Approaches used in the past to address the question of why some P. aeruginosa strains are more virulent than others will now be applied to another hospital-acquired pathogen: Acinetobacter baumannii. Accessory genomic elements (genetic material found in some strains but not in others) will be identified that encode pathogenic factors and enhance the virulence of strains containing them. These markers for hypervirulent strains will be validated in human patients with A. baumannii infections. Both these projects further characterize disease mechanism by utilizing studies involving face-to-face contact with patients. They are thus ideal training vehicles for junior clinician investigators. In summary, this K24 award will provide salary support and research funds to allow Dr. Hauser to spend more of his time mentoring clinical fellows in patient-oriented research, to expand his patient-oriented research activities, and to enhance his mentoring skills.

Public Health Relevance

This K24 award provides salary support for Dr. Hauser to allow him to spend 33% of his time mentoring MD fellows, performing patient-oriented research, and enhancing his mentoring skills. The expanded research program in patient-oriented research will focus on the hospital-acquired pathogens Pseudomonas aeruginosa and Acinetobacter baumannii, and will provide ideal vehicles for the training of junior clinician investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24AI104831-01
Application #
8488210
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Korpela, Jukka K
Project Start
2013-07-10
Project End
2018-06-30
Budget Start
2013-07-10
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$100,048
Indirect Cost
$7,411
Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Berube, Bryan J; Rangel, Stephanie M; Hauser, Alan R (2016) Pseudomonas aeruginosa: breaking down barriers. Curr Genet 62:109-13
Fitzpatrick, Margaret A; Ozer, Egon A; Hauser, Alan R (2016) Utility of Whole-Genome Sequencing in Characterizing Acinetobacter Epidemiology and Analyzing Hospital Outbreaks. J Clin Microbiol 54:593-612
Ozer, Egon A; Morris, Andrew R; Krapp, Fiorella et al. (2016) Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source. Genome Announc 4:
Tyson, Gregory H; Halavaty, Andrei S; Kim, Hyunjin et al. (2015) A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases. J Biol Chem 290:2919-37
Zhang, Angelica; Rangel, Stephanie M; Hauser, Alan R (2015) The great escape: Pseudomonas breaks out of the lung. Microb Cell 2:409-411
Fitzpatrick, Margaret A; Ozer, Egon; Bolon, Maureen K et al. (2015) Influence of ACB complex genospecies on clinical outcomes in a U.S. hospital with high rates of multidrug resistance. J Infect 70:144-52
Rangel, Stephanie M; Logan, Latania K; Hauser, Alan R (2014) The ADP-ribosyltransferase domain of the effector protein ExoS inhibits phagocytosis of Pseudomonas aeruginosa during pneumonia. MBio 5:e01080-14
Chuang, Chih-Hsien; Wang, Yi-Hsin; Chang, Hsin-Ju et al. (2014) Shanghai fever: a distinct Pseudomonas aeruginosa enteric disease. Gut 63:736-43
Allen, Jonathan P; Ozer, Egon A; Hauser, Alan R (2014) Different paths to pathogenesis. Trends Microbiol 22:168-9
Wang, Nengding; Ozer, Egon A; Mandel, Mark J et al. (2014) Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung. MBio 5:e01163-14

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