Childhood asthma, particularly in urban environments, is a source of significant morbidity. Children spend the majority of their day in school. The immediate goal of this project is to determine the role of changes in school-specific environmental exposures and genetic factors and asthma morbidity. The Candidate/PI is a board-certified allergist/immunologist with a MS in clinical epidemiology and runs a NIH funded asthma/allergy clinical research center. She has expertise in patient-oriented clinical research and mentoring. Her environment includes unparalleled community relationships, infrastructure, resources, and collaborators. Career Development Goals are to ensure that the candidate will be provided sufficient time for mentoring and patient oriented clinical research activities. The award will also allow her to further her education in statistical methods, study design, and gene-environment interactions to help her expand her patient oriented research program. This will allow us to move towards our overall goal of further our understanding of epigenetic/environmental interactions to design and implement more effective school focused interventions to reduce the severity and incidence of childhood asthma. The research hypothesis is that changes in classroom/school specific allergen/mold exposure levels will be associated with epigenetic changes in methylation, airway inflammation, and asthma symptoms. We will compare our methylation markers on selected genes potentially important in asthma with changes in the classroom-specific allergen/mold exposure and asthma health outcomes. We will also compare these results in a subset of age/gender matched students without asthma as controls attending the same classrooms to further the interpretation of our findings. The impact of this research may result in novel biomarkers that could inform us about the efficacy of school-based interventions against environmental exposures important to childhood asthma and its immune modulation, addressing a critical public health problem.

Public Health Relevance

We aim to determine the role of changes in school-specific environmental exposures and genetic/epigenetic factors and asthma morbidity. By furthering our understanding of mechanisms behind modifiable epigenetic/environmental risk factors, we may be able to design and implement more cost and time efficient school-based environmental interventions that may potentially help a community of children with asthma, allergic diseases, and its associated morbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI106822-02
Application #
8667990
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2013-06-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$183,061
Indirect Cost
$13,560
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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Jhun, Iny; Phipatanakul, Wanda (2016) Early exposure to dogs and farm animals reduces risk of childhood asthma. Evid Based Med 21:80
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Lu, Kim D; Phipatanakul, Wanda; Perzanowski, Matthew S et al. (2016) Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma 53:1033-44
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Gaffin, Jonathan M; Petty, Carter R; Hauptman, Marissa et al. (2016) Modeling indoor particulate exposures in inner-city school classrooms. J Expo Sci Environ Epidemiol :
Wright, Lakiea S; Phipatanakul, Wanda (2016) Treatment of moderate to severe pediatric asthma: Omalizumab and potential future use of monoclonal antibodies. Ann Allergy Asthma Immunol 117:17-20
Lemanske Jr, Robert F; Kakumanu, Sujani; Shanovich, Kathleen et al. (2016) Creation and implementation of SAMPRO™: A school-based asthma management program. J Allergy Clin Immunol 138:711-23
Hauptman, Marissa; Phipatanakul, Wanda (2016) Recent advances in environmental controls outside the home setting. Curr Opin Allergy Clin Immunol 16:135-41

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