Childhood asthma, particularly in urban environments, is a source of significant morbidity. Children spend the majority of their day in school. The immediate goal of this project is to determine the role of changes in school-specific environmental exposures and genetic factors and asthma morbidity. The Candidate/PI is a board-certified allergist/immunologist with a MS in clinical epidemiology and runs a NIH funded asthma/allergy clinical research center. She has expertise in patient-oriented clinical research and mentoring. Her environment includes unparalleled community relationships, infrastructure, resources, and collaborators. Career Development Goals are to ensure that the candidate will be provided sufficient time for mentoring and patient oriented clinical research activities. The award will also allow her to further her education in statistical methods, study design, and gene-environment interactions to help her expand her patient oriented research program. This will allow us to move towards our overall goal of further our understanding of epigenetic/environmental interactions to design and implement more effective school focused interventions to reduce the severity and incidence of childhood asthma. The research hypothesis is that changes in classroom/school specific allergen/mold exposure levels will be associated with epigenetic changes in methylation, airway inflammation, and asthma symptoms. We will compare our methylation markers on selected genes potentially important in asthma with changes in the classroom-specific allergen/mold exposure and asthma health outcomes. We will also compare these results in a subset of age/gender matched students without asthma as controls attending the same classrooms to further the interpretation of our findings. The impact of this research may result in novel biomarkers that could inform us about the efficacy of school-based interventions against environmental exposures important to childhood asthma and its immune modulation, addressing a critical public health problem.

Public Health Relevance

We aim to determine the role of changes in school-specific environmental exposures and genetic/epigenetic factors and asthma morbidity. By furthering our understanding of mechanisms behind modifiable epigenetic/environmental risk factors, we may be able to design and implement more cost and time efficient school-based environmental interventions that may potentially help a community of children with asthma, allergic diseases, and its associated morbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI106822-02
Application #
8667990
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2013-06-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$183,061
Indirect Cost
$13,560
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Gaffin, Jonathan M; Hauptman, Marissa; Petty, Carter R et al. (2017) Nitrogen dioxide exposure in school classrooms of inner-city children with asthma. J Allergy Clin Immunol :
Gaffin, Jonathan M; Phipatanakul, Wanda (2017) The Calculated Risk of Childhood Asthma From Severe Bronchiolitis. J Allergy Clin Immunol Pract 5:97-98
Phipatanakul, Wanda; Koutrakis, Petros; Coull, Brent A et al. (2017) The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned. Contemp Clin Trials 60:14-23
Louisias, Margee; Phipatanakul, Wanda (2017) Managing Asthma in Low-Income, Underrepresented Minority, and Other Disadvantaged Pediatric Populations: Closing the Gap. Curr Allergy Asthma Rep 17:68
Matsui, Elizabeth C; Perzanowski, Matthew; Peng, Roger D et al. (2017) Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial. JAMA 317:1027-1036
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Sheehan, William J; Brough, Helen A; Makinson, Kerry et al. (2017) Distribution of peanut protein in school and home environments of inner-city children. J Allergy Clin Immunol 140:1724-1726
Dilley, Meredith A; Petty, Carter R; Sheehan, William J et al. (2017) Adherence and stress in a population of inner-city children with asthma. Pediatr Allergy Immunol 28:610-612
Bartnikas, Lisa M; Huffaker, Michelle F; Sheehan, William J et al. (2017) Impact of school peanut-free policies on epinephrine administration. J Allergy Clin Immunol 140:465-473
Jhun, Iny; Gaffin, Jonathan M; Coull, Brent A et al. (2017) School Environmental Intervention to Reduce Particulate Pollutant Exposures for Children with Asthma. J Allergy Clin Immunol Pract 5:154-159.e3

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