The candidate is currently an Associate Professor of Pediatrics at Johns Hopkins and a pediatric allergist/immunologist, epidemiologist, and environmental health scientist whose broad career goal is to develop an understanding of the effects of the environment on asthma that results in feasible and actionable public health interventions to prevent asthma and reduce asthma morbidity. As the complex interplay between microbes, allergens, and pollutants must be understood in order to make significant progress in environmental control strategies for prevention and treatment of allergic disease, one major aim of this project is to extend her research program to study the effects of environmental microbial exposures on asthma. In addition, the candidate has a strong track record of mentoring trainees in patient-oriented research (POR) and proposes to develop advanced mentorship skills with a combination of didactic and mentored learning. Thus, the second aim of this proposal is to protect her time for mentorship and further development of mentoring skills. The mentorship skills and research development will occur, in part, in the context of the proposed research project, which aims to test the hypothesis that environmental exposure to SE+ S. aureus causes asthma morbidity in urban children in a SE-specific IgE dependent manner.

Public Health Relevance

This Midcareer Investigator Award in Patient-Oriented Research will have two major public health impacts. First, it will expand the pool of highly trained investigators in patient-oriented research; and second, the research program will lend new insights into the effects of environmental microbial exposures on asthma in inner-city children, a group that continues to have disproportionate asthma morbidity.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Allergy, Immunology, and Transplantation Research Committee (AITC)
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Gondre-Lewis, Timothy A
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Johns Hopkins University
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Ahluwalia, Sharon K; Matsui, Elizabeth C (2018) Indoor Environmental Interventions for Furry Pet Allergens, Pest Allergens, and Mold: Looking to the Future. J Allergy Clin Immunol Pract 6:9-19
Gordon, Julian; Reboulet, Rachel; Gandhi, Prasanthi et al. (2018) Validation of a novel sampling technology for airborne allergens in low-income urban homes. Ann Allergy Asthma Immunol 120:96-97.e1
Wu, Tianshi David; Brigham, Emily P; Peng, Roger et al. (2018) Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. J Allergy Clin Immunol Pract 6:2157-2159.e5
Davis, Meghan F; Ludwig, Shanna; Brigham, Emily P et al. (2018) Effect of home exposure to Staphylococcus aureus on asthma in adolescents. J Allergy Clin Immunol 141:402-405.e10
Grant, Torie; Aloe, Charles; Perzanowski, Matthew et al. (2017) Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children. J Allergy Clin Immunol Pract 5:1008-1014.e1
Hughes, Helen K; Matsui, Elizabeth C; Tschudy, Megan M et al. (2017) Pediatric Asthma Health Disparities: Race, Hardship, Housing, and Asthma in a National Survey. Acad Pediatr 17:127-134
Matsui, Elizabeth C; Keet, Corinne A (2017) Weighing the evidence: Bias and confounding in epidemiologic studies in allergy/immunology. J Allergy Clin Immunol 139:448-450
Matsui, Elizabeth C; Perzanowski, Matthew; Peng, Roger D et al. (2017) Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial. JAMA 317:1027-1036
Miller, Rachel L; Zhang, Hanjie; Jezioro, Jacqueline et al. (2017) Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children. Environ Res 156:619-624
Ludwig, Shanna; Jimenez-Bush, Isabel; Brigham, Emily et al. (2017) Analysis of home dust for Staphylococcus aureus and staphylococcal enterotoxin genes using quantitative PCR. Sci Total Environ 581-582:750-755

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