The candidate is currently an Associate Professor of Pediatrics at Johns Hopkins and a pediatric allergist/immunologist, epidemiologist, and environmental health scientist whose broad career goal is to develop an understanding of the effects of the environment on asthma that results in feasible and actionable public health interventions to prevent asthma and reduce asthma morbidity. As the complex interplay between microbes, allergens, and pollutants must be understood in order to make significant progress in environmental control strategies for prevention and treatment of allergic disease, one major aim of this project is to extend her research program to study the effects of environmental microbial exposures on asthma. In addition, the candidate has a strong track record of mentoring trainees in patient-oriented research (POR) and proposes to develop advanced mentorship skills with a combination of didactic and mentored learning. Thus, the second aim of this proposal is to protect her time for mentorship and further development of mentoring skills. The mentorship skills and research development will occur, in part, in the context of the proposed research project, which aims to test the hypothesis that environmental exposure to SE+ S. aureus causes asthma morbidity in urban children in a SE-specific IgE dependent manner.

Public Health Relevance

This Midcareer Investigator Award in Patient-Oriented Research will have two major public health impacts. First, it will expand the pool of highly trained investigators in patient-oriented research; and second, the research program will lend new insights into the effects of environmental microbial exposures on asthma in inner-city children, a group that continues to have disproportionate asthma morbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI114769-04
Application #
9415461
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2015-02-01
Project End
2020-01-31
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Hughes, Helen K; Matsui, Elizabeth C; Tschudy, Megan M et al. (2017) Pediatric Asthma Health Disparities: Race, Hardship, Housing, and Asthma in a National Survey. Acad Pediatr 17:127-134
Matsui, Elizabeth C; Perzanowski, Matthew; Peng, Roger D et al. (2017) Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial. JAMA 317:1027-1036
Miller, Rachel L; Zhang, Hanjie; Jezioro, Jacqueline et al. (2017) Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children. Environ Res 156:619-624
Ludwig, Shanna; Jimenez-Bush, Isabel; Brigham, Emily et al. (2017) Analysis of home dust for Staphylococcus aureus and staphylococcal enterotoxin genes using quantitative PCR. Sci Total Environ 581-582:750-755
Kantor, David B; Stenquist, Nicole; McDonald, Molly C et al. (2016) Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children. J Allergy Clin Immunol 138:1467-1471.e9
McCormack, Meredith C; Belli, Andrew J; Waugh, Darryn et al. (2016) Respiratory Effects of Indoor Heat and the Interaction with Air Pollution in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 13:2125-2131
McGowan, Emily C; Matsui, Elizabeth C; Peng, Roger et al. (2016) Racial/ethnic and socioeconomic differences in self-reported food allergy among food-sensitized children in National Health and Nutrition Examination Survey III. Ann Allergy Asthma Immunol 117:570-572.e3
Sedaghat, Ahmad R; Matsui, Elizabeth C; Baxi, Sachin N et al. (2016) Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma. J Allergy Clin Immunol Pract 4:82-8.e1
Lu, Kim D; Phipatanakul, Wanda; Perzanowski, Matthew S et al. (2016) Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma 53:1033-44
Sudini, Kuladeep; Diette, Gregory B; Breysse, Patrick N et al. (2016) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics. J Allergy Clin Immunol Pract 4:932-40

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