The K24 Mid-Career Mentoring and Research Award has permitted me to establish one of the few Musculoskeletal and Orthopaedic Clinical Research Training Programs and Research Units in the US. During the period of the award, I have published 68 papers, most as senior author, received six grants as Principal Investigator, and worked with over 25 mentees. My trainees have received two K23 awards, an R03 grant, and three other career development awards. All of this work has centered on musculoskeletal disorders and orthopaedic interventions. In this competitive renewal application, I request five additional years of K24 funding to enlarge and strengthen the mentoring and research programs. Specifically, I aim: 1. To further develop a clinical research-training program that will prepare the next generation of clinical investigators for rigorous study of musculoskeletal conditions and orthopaedic interventions, and will develop the next generation of mentors in clinical and musculoskeletal and orthopaedic research. 2. To expand my patient-oriented research rogram. In addition to continuing work on total hip and knee arthroplasty, and spinal and upper extremity disorders, I propose to critically evaluate the role of arthroscopic partial meniscectomy (APM) in patients with symptomatic meniscal tear and concomitant knee osteoarthritis. We plan a randomized controlled trial of APM as compared with a rigorous nonoperative regimen in 340 patients in five or six centers. The trial will evaluate the efficacy and cost effectiveness of APM as compared to nonoperative therapy and identify predictors of outcome. The trial, as well as my other research programs, will provide rich mentored research opportunities for trainees.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZAR1-TLB-D (O1))
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Panagis, James S
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Brigham and Women's Hospital
United States
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Suri, P; Hunter, D J; Rainville, J et al. (2013) Presence and extent of severe facet joint osteoarthritis are associated with back pain in older adults. Osteoarthritis Cartilage 21:1199-206
Perruccio, Anthony V; Losina, Elena; Wright, Elizabeth A et al. (2013) Aggregate health burden and the risk of hospitalization in older persons post hip replacement surgery. J Gerontol A Biol Sci Med Sci 68:293-300
Losina, Elena; Wright, James; Katz, Jeffrey N (2012) Clinical trials in orthopaedics research. Part III. Overcoming operational challenges in the design and conduct of randomized clinical trials in orthopaedic surgery. J Bone Joint Surg Am 94:e35
Perruccio, Anthony V; Katz, Jeffrey N; Losina, Elena (2012) Health burden in chronic disease: multimorbidity is associated with self-rated health more than medical comorbidity alone. J Clin Epidemiol 65:100-6
Solomon, Daniel H; Iversen, Maura D; Avorn, Jerry et al. (2012) Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial. Arch Intern Med 172:477-83
Suri, Pradeep; Hunter, David J; Rainville, James et al. (2012) Quantitative assessment of abdominal aortic calcification and associations with lumbar intervertebral disc height loss: the Framingham Study. Spine J 12:315-23
Iversen, Maura D; Chudasama, Nidhi; Losina, Elena et al. (2011) Influence of self-reported limb length discrepancy on function and satisfaction 6 years after total hip replacement. J Geriatr Phys Ther 34:148-52
Reichmann, William M; Katz, Jeffrey N; Losina, Elena (2011) Differences in self-reported health in the Osteoarthritis Initiative (OAI) and Third National Health and Nutrition Examination Survey (NHANES-III). PLoS One 6:e17345
Losina, Elena; Walensky, Rochelle P; Reichmann, William M et al. (2011) Impact of obesity and knee osteoarthritis on morbidity and mortality in older Americans. Ann Intern Med 154:217-26
Suri, Pradeep; Rainville, James; Katz, Jeffrey N et al. (2011) The accuracy of the physical examination for the diagnosis of midlumbar and low lumbar nerve root impingement. Spine (Phila Pa 1976) 36:63-73

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