Abstract

David J. Margolis, MD PhD is currently an Associate Professor of Dermatology, an Associate Professor of Epidemiology in the Department of Biostatistics and Epidemiology, and a Senior Scholar (core faculty member) in the Center for Clinical Epidemiology and Biostatistics of the University of Pennsylvania. He is an established patient-oriented researcher with an extensive track record of successful research. His research record attests to his commitment to a career in patient-oriented research, which has been focused on the prevention and treatment of chronic wounds, and his desire to be a mentor. He has applied a wide variety of epidemiologic tools and patient-oriented research methods to address research issues. His immediate and long-term career goals center on his desire and intention to continue to evolve and mature as a patient-oriented researcher, teacher, and mentor. Resources available to him,on and around the Penn campus, include all of the components necessary for successful patient-oriented research and mentoring including biostatistical support, data management support, and state of the art research/clinical laboratory services. His patient-oriented NAIMS-funded research project is, after many years of delay, in its first of five years. Most patients with chronic wounds of the lower extremity fail to heal in a reasonable period of time. We have hypothesized that a growth factor associated with wound healing PDGF-BB, when produced in large quantities within the wound bed due to adenovirus mediated gene overexpression by the cells of the wound bed, will dramatically enhance wound healing. This study will use a unique and innovative gene therapy approach, adenovirus-Ad5 and the PDGF-B gene, to insure delivery of a cytokine growth factor to a non-healing wound.
The aim of the proposed research study is to assess whether PDGF-BB via in vivo PDGF-BB gene transduction via an intra-ulcer injection of H5.020CMVPDGF-B in patients with a chronic venous leg ulcers can induce the local acquisition of endothelial precursor cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR002212-10
Application #
7789548
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
2001-05-01
Project End
2013-03-31
Budget Start
2010-04-01
Budget End
2013-03-31
Support Year
10
Fiscal Year
2010
Total Cost
$125,218
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Dermatology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Sargen, Michael R; Hoffstad, Ole; Margolis, David J (2013) Geographic variation in Medicare spending and mortality for diabetic patients with foot ulcers and amputations. J Diabetes Complications 27:128-33
Margolis, David J; Gupta, Jayanta; Thom, Stephen R et al. (2013) Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study. Wound Repair Regen 21:17-24
Sargen, Michael R; Hoffstad, Ole J; Wiebe, Douglas J et al. (2012) Geographic variation in pharmacotherapy decisions for U.S. Medicare enrollees with diabetes. J Diabetes Complications 26:301-7
Margolis, David J; Hoffstad, Ole; Nafash, Jeffrey et al. (2011) Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes. Diabetes Care 34:2363-7
Thom, Stephen R; Milovanova, Tatyana N; Yang, Ming et al. (2011) Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen 19:149-61
Margolis, David J; Hoffstad, Ole; Thom, Stephen et al. (2010) The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes. Wound Repair Regen 18:445-51
Margolis, David J; Morris, Lee M; Papadopoulos, Maryte et al. (2009) Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease. Mol Ther 17:1822-9
Kurd, Shanu K; Hoffstad, Ole J; Bilker, Warren B et al. (2009) Evaluation of the use of prognostic information for the care of individuals with venous leg ulcers or diabetic neuropathic foot ulcers. Wound Repair Regen 17:318-25
Margolis, David J; Hoffstad, Ole; Strom, Brian L (2008) Association between serious ischemic cardiac outcomes and medications used to treat diabetes. Pharmacoepidemiol Drug Saf 17:753-9
Margolis, David J; Hofstad, Ole; Feldman, Harold I (2008) Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes. Diabetes Care 31:1331-6

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