Nancy E. Lane, is a clinical rheumatologist and an active clinical investigator in musculoskeletal diseases with a special emphasis on osteoarthritis and osteoporosis. She is currently an NIH funded investigator conducting research on the epidemiology and genetics of prevalent and progression of hip and knee osteoarthritis. The purpose of this K24 award renewal is to continue to mentor and teach clinical research in musculoskeletal diseases at U.C. Davis School of Medicine and the University of California at San Francisco (UCSF) to junior clinical investigators by 1) Continuing the twice a month interdisciplinary clinical research seminars in musculoskeletal diseases with research presentations by junior investigators;2) Teaching a seminar to junior investigators and medical students at UCDMC on Developing a Clinical Research Protocol;4) Mentoring junior investigators in clinical and translational research with my currently funded NIH grants on the epidemiology and genetics of hip OA and Knee OA in elderly men and women;5) To be mentored senior investigators in genetic epidemiology and statistics so as to become an expert in both the epidemiology and genetics of OA..
The specific aims of the three NIH grants that Dr. Lane will use to mentor junior investigators and to gain a more thorough understanding of genetic epidemiology include 1. "The epidemiology and genetics of hip OA in elderly men" are to determine the prevalence of radiographic hip OA in a cohort of 5000 elderly men, determine risk factors and genetic variants associated with prevalent hip OA. 2. "The natural history of hip OA in elderly women" are to identify cases of new or worsening radiographic osteoarthritis of the hip and then to determine risk factors for hip OA. 3."Multiple Outcomes in Osteoarthritis study (MOST)" are to longitudinally evaluate the effects of three groups of factors: biomechanical factors (including physical activity-related factors), bone/structural factors and nutritional factors on the occurrence and progression of symptomatic knee OA and radiographic knee OA in a population-based sample of 3000 men and women aged 50 to 79. In total, this award will enhance the achievements of the initial K-Award by building on and solidifying the strong base of research and mentoring in musculoskeletal diseases developed within the first K-Award while taking advantage of, and melding with, the strong interest in genetics and translational research that defines the current environment of the UC Davis School of Medicine

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Chen, Faye H
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University of California Davis
Internal Medicine/Medicine
Schools of Medicine
United States
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Lee, Sonia; Nardo, Lorenzo; Kumar, Deepak et al. (2015) Scoring hip osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system. J Magn Reson Imaging 41:1549-57
Yao, Wei; Lane, Nancy E (2015) Targeted delivery of mesenchymal stem cells to the bone. Bone 70:62-5
Chaudhari, Abhijit J; Leahy, Richard M; Wise, Barton L et al. (2014) Global point signature for shape analysis of carpal bones. Phys Med Biol 59:961-73
Wise, Barton L; Parimi, Neeta; Zhang, Yuqing et al. (2014) Frailty and hip osteoarthritis in men in the MrOS cohort. J Gerontol A Biol Sci Med Sci 69:602-8
Amugongo, Sarah K; Yao, Wei; Jia, Junjing et al. (2014) Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats. Bone 67:257-68
Szulc, Pawel; Blackwell, Terri; Schousboe, John T et al. (2014) High hip fracture risk in men with severe aortic calcification: MrOS study. J Bone Miner Res 29:968-75
Wise, B L; Kritikos, L; Lynch, J A et al. (2014) Proximal femur shape differs between subjects with lateral and medial knee osteoarthritis and controls: the Osteoarthritis Initiative. Osteoarthritis Cartilage 22:2067-73
Smagula, Stephen F; Ancoli-Israel, Sonia; Barrett-Connor, Elizabeth et al. (2014) Inflammation, sleep disturbances, and depressed mood among community-dwelling older men. J Psychosom Res 76:368-73
Amugongo, S K; Yao, W; Jia, J et al. (2014) Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass. Osteoporos Int 25:1735-50
Lane, Nancy E; Parimi, Neeta; Corr, Maripat et al. (2013) Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res 28:2325-32

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