Osteoporosis is a significant concern for both older men and women. Recent studies suggest skeletal biomarkers might provide important information about the biologic causes of osteoporosis and may be useful to predict fracture alone or when combined with other risk factors. To extend his ongoing NIH-funded work on biomarkers and skeletal fragility, Dr. Douglas Bauer, Professor of Medicine, Epidemiology &Biostatistics at the University of California, San Francisco, is requesting a renewal of his K24 Midcareer Investigator Award in Patient-Oriented Research with the scientific goals of developing new and clinically useful proteomic biomarkers using data from a well characterized longitudinal cohort of older men (MrOS). Taking advantage of ongoing assessments for fracture and recent funding for proteomic measurements in serum collected at baseline, this study will explore the prospective relationship between proteomic profile and incident vertebral fracture in 3000 MrOS participants. Using these and other data from multiple large studies available through his longstanding affiliation with the San Francisco Coordinating Center, Dr. Bauer will continue to mentor young investigators who are interested in clinical research, particularly residents. With the initial K24 award Dr. Bauer mentored residents and fellows who are now pursuing additional research training and academic careers. In conjunction with the UCSF Clinical and Translational Science Institute, during the initial K24 award he also developed and directed a new comprehensive Resident Research Program. The goal of this novel program is to promote clinical research careers by providing residents with formal instruction in research methods, pilot funding and opportunities to participate in mentored research projects. The continuation of this K24 award is critical to protect Dr. Bauer's time and allow him to continue to make significant contributions towards patient-oriented research related to biomarkers and skeletal fragility and to expand his successful mentoring program.

Public Health Relevance

Osteoporotic fractures are an important public health concern. This project will build on previous work by the applicant to understand the biologic factors associated with osteoporotic fractures, particularly in men. The project will also allow the application to continue and expand his successful mentoring program for junior investigators who are interested in patient-oriented research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Chen, Faye H
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Jamal, Sophie A; Arampatzis, Spyridon; Harrison, Stephanie Litwack et al. (2015) Hyponatremia and Fractures: Findings From the MrOS Study. J Bone Miner Res 30:970-5
Weiler, Stefan; Gemperli, Armin; Collet, Tinh-Hai et al. (2014) Clinically relevant quality measures for risk factor control in primary care: a retrospective cohort study. BMC Health Serv Res 14:306
McNabb, Brian; Vittinghoff, Eric; Eastell, Richard et al. (2014) A model of BMD changes after alendronate discontinuation to guide postalendronate BMD monitoring. J Clin Endocrinol Metab 99:4094-100
Gencer, Baris; Butler, Javed; Bauer, Douglas C et al. (2014) Association of electrocardiogram abnormalities and incident heart failure events. Am Heart J 167:869-75.e3
Virgini, Vanessa S; Wijsman, Liselotte W; Rodondi, Nicolas et al. (2014) Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid 24:208-14
Collet, Tinh-Hai; Bauer, Douglas C; Cappola, Anne R et al. (2014) Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis. J Clin Endocrinol Metab 99:3353-62
Hue, Trisha F; Cummings, Steven R; Cauley, Jane A et al. (2014) Effect of bisphosphonate use on risk of postmenopausal breast cancer: results from the randomized clinical trials of alendronate and zoledronic acid. JAMA Intern Med 174:1550-7
Bauer, Douglas C; Schwartz, Ann; Palermo, Lisa et al. (2014) Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: the FLEX study. JAMA Intern Med 174:1126-34
Bauer, Douglas C (2014) The calcium supplement controversy: now what? J Bone Miner Res 29:531-3
Szulc, Pawel; Blackwell, Terri; Schousboe, John T et al. (2014) High hip fracture risk in men with severe aortic calcification: MrOS study. J Bone Miner Res 29:968-75

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