This application proposes a renewal of a Midcareer Investigator Award in Patient-Oriented Research for Mary-Margaret Chren, MD, Professor of Dermatology at the University of California, San Francisco (UCSF). Dr. Chren's long-term career objectives are to perform rigorous research to improve the health of patients with skin diseases, and to use her research to develop first-rate investigators in patient-oriented research in skin diseases. This renewed award will build on her previous work and accomplish her immediate career objectives: first, to expand and complete the next phase of the Nonmelanoma Skin Cancer (NMSC) Cohort Study, a 10-year comparative effectiveness study of treatments for NMSC (the most common malignancy);second, to build on these findings to develop and perform a targeted multicenter clinical trial of treatments for NMSC;third, to use these research data as a substrate for the mentoring of clinician investigators in patient-oriented research;and fourth, to increase the scope of her mentoring activity by serving an expanded leadership role with the Mentorship Development Program of the UCSF Clinical &Translational Science Institute (CTSI). The proposed research will fill a gap in current knowledge about the comparative efficacy of the two most common treatments for NMSC, surgical excision and histologically-guided serial excision, or Mohs surgery. The research will undertake the incremental developmental steps to design and conduct a multicenter randomized controlled trial of excision and Mohs surgery for primary facial basal cell carcinomas (BCC). These steps include establishment of research, clinical, and stakeholder advisory groups, composition of study tools, drafting of study procedures, and pilot-testing of procedures. After infrastructure development, 1200 patients with primary facial BCC will be randomized to surgical excision or Mohs surgery. The primary outcome is tumor recurrence at five years;secondary outcome is skin-related quality of life. The proposed mentoring plan has three parts: didactic curricula, "hands-on" research, and career development;with the renewed award, didactic options will be fully integrated with CTSI's comprehensive program of highly-directed courses. This enhanced integration will be fostered by Dr. Chren's role as leader of the Mentor Evaluation Plan for the CTSI's Mentorship Development Program. Together, the Research Plan and Mentoring Plan provide a new five-year strategy that is directly relevant to the NIH and NIAMS missions of pursuing and applying knowledge to reduce disease burden, and training scientists to carry out such research.

Public Health Relevance

This application proposes renewal of an award to support a mentoring program in patient-oriented research in skin diseases, using an expanded research program on improving care for nonmelanoma skin cancer. The proposal is relevant to the public health because it focuses on ensuring that sufficient numbers of highly-trained and well- mentored scientists are available to perform top-quality research on health care and how to improve it. In addition, rigorous studies are needed to compare different treatments for nonmelanoma skin cancer, which is the most common malignancy;the work proposed in this application addresses that public health need.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR052667-09
Application #
8528470
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
2005-07-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$182,524
Indirect Cost
$13,520
Name
University of California San Francisco
Department
Dermatology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Galles, Elyse; Parvataneni, Rupa; Stuart, Sarah E et al. (2014) Patient-reported outcomes of electrodessication and curettage for treatment of nonmelanoma skin cancer. J Am Acad Dermatol 71:1026-8
Katz, Kenneth A; Reid, Erika E; Chren, Mary-Margaret (2014) Drug samples in dermatology: out of the closet, into the dustbin. JAMA Dermatol 150:483-5
Linos, Eleni; Schroeder, Steven A; Chren, Mary-Margaret (2014) Potential overdiagnosis of basal cell carcinoma in older patients with limited life expectancy. JAMA 312:997-8
He, Steven Y; McCulloch, Charles E; Boscardin, W John et al. (2014) Self-reported pigmentary phenotypes and race are significant but incomplete predictors of Fitzpatrick skin phototype in an ethnically diverse population. J Am Acad Dermatol 71:731-7
Wehner, Mackenzie R; Chren, Mary-Margaret; Nameth, Danielle et al. (2014) International prevalence of indoor tanning: a systematic review and meta-analysis. JAMA Dermatol 150:390-400
Linos, Eleni; Wehner, Mackenzie R; Frosch, Dominick L et al. (2013) Patient-reported problems after office procedures. JAMA Intern Med 173:1249-50
Hausauer, Amelia K; Maurer, Toby; Leslie, Kieron S et al. (2013) Recurrence after treatment of cutaneous basal cell and squamous cell carcinomas in patients infected with human immunodeficiency virus. JAMA Dermatol 149:239-41
Chren, Mary-Margaret; Linos, Eleni; Torres, Jeanette S et al. (2013) Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. J Invest Dermatol 133:1188-96
Linos, Eleni; Parvataneni, Rupa; Stuart, Sarah E et al. (2013) Treatment of nonfatal conditions at the end of life: nonmelanoma skin cancer. JAMA Intern Med 173:1006-12
Shive, Melissa; Linos, Eleni; Berger, Timothy et al. (2013) Itch as a patient-reported symptom in ambulatory care visits in the United States. J Am Acad Dermatol 69:550-6

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