The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to """"""""change the outcomes"""""""" for pediatric patients.

Public Health Relevance

(See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR056687-05
Application #
8512662
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Serrate-Sztein, Susana
Project Start
2009-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$110,061
Indirect Cost
$8,153
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Kashikar-Zuck, Susmita; Cunningham, Natoshia; Peugh, James et al. (2018) Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time. Pain :
Kashikar-Zuck, Susmita; Black, William R; Pfeiffer, Megan et al. (2018) Pilot Randomized Trial of Integrated Cognitive-Behavioral Therapy and Neuromuscular Training for Juvenile Fibromyalgia: The FIT Teens Program. J Pain 19:1049-1062
Lynch-Jordan, Anne M; Peugh, James; Cunningham, Natoshia R et al. (2018) Maternal Protective Parenting Accounts for the Relationship Between Pain Behaviors and Functional Disability in Adolescents. Clin J Pain 34:1089-1095
Cunningham, Natoshia R; Nelson, Sarah; Jagpal, Anjana et al. (2018) Development of the Aim to Decrease Anxiety and Pain Treatment for Pediatric Functional Abdominal Pain Disorders. J Pediatr Gastroenterol Nutr 66:16-20
Cunningham, Natoshia R; Jagpal, Anjana; Nelson, Sarah et al. (2018) Clinical Reference Points for the Screen for Child Anxiety Related Disorders in Two Investigations of Youth with Chronic Pain. Clin J Pain :
Donnelly, C; Cunningham, N; Jones, J T et al. (2018) Fatigue and depression predict reduced health-related quality of life in childhood-onset lupus. Lupus 27:124-133
Ali, Ather; Weiss, Theresa R; Dutton, Anne et al. (2017) Mindfulness-Based Stress Reduction for Adolescents with Functional Somatic Syndromes: A Pilot Cohort Study. J Pediatr 183:184-190
Cunningham, Natoshia R; Jagpal, Anjana; Peugh, James et al. (2017) Risk Categorization Predicts Disability in Pain-associated Functional Gastrointestinal Disorders After 6 Months. J Pediatr Gastroenterol Nutr 64:685-690
Kroon Van Diest, Ashley M; Ramsey, Rachelle R; Kashikar-Zuck, Susmita et al. (2017) Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. Clin J Pain 33:892-898
King, Christopher D; Jastrowski Mano, Kristen E; Barnett, Kimberly A et al. (2017) Pressure Pain Threshold and Anxiety in Adolescent Females With and Without Juvenile Fibromyalgia: A Pilot Study. Clin J Pain 33:620-626

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