This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Associate Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 10 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both are from NIBIB). Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (40% salary) for 5 years. This funding will guarantee that the candidate will have at least 50% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the two ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions.

Public Health Relevance

Musculoskeletal diseases such as osteoarthritis have a tremendous impact on the individual and society as a whole. We need better imaging tools to detect these diseases at an early, treatable stage. This K24 award will permit the PI to increase his efforts in mentoring junior investigators in patient-oriented research, and to conduct research to improve detection, understanding, and treatment of patients with musculoskeletal disease.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Lester, Gayle E
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Stanford University
Schools of Medicine
United States
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Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2016) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med :
Monu, U D; Jordan, C D; Samuelson, B L et al. (2016) Cluster analysis of quantitative MRI T2 and T1ρ relaxation times of cartilage identifies differences between healthy and ACL-injured individuals at 3T. Osteoarthritis Cartilage :
Choi, Soo-Jung; Koch, Kevin M; Hargreaves, Brian A et al. (2015) Metal artifact reduction with MAVRIC SL at 3-T MRI in patients with hip arthroplasty. AJR Am J Roentgenol 204:140-7
Zöllner, Alexander M; Pok, Jacquelynn M; McWalter, Emily J et al. (2015) On high heels and short muscles: a multiscale model for sarcomere loss in the gastrocnemius muscle. J Theor Biol 365:301-10
Johnson, Dustin; Stevens, Kathryn J; Riley, Geoffrey et al. (2015) Approach to MR Imaging of the Elbow and Wrist: Technical Aspects and Innovation. Magn Reson Imaging Clin N Am 23:355-66
Gutierrez, Luis B; Do, Bao H; Gold, Garry E et al. (2015) MR imaging near metallic implants using MAVRIC SL: initial clinical experience at 3T. Acad Radiol 22:370-9
Wentland, Andrew L; McWalter, Emily J; Pal, Saikat et al. (2015) Muscle velocity and inertial force from phase contrast MRI. J Magn Reson Imaging 42:526-32
Matzat, Stephen J; McWalter, Emily J; Kogan, Feliks et al. (2015) T2 Relaxation time quantitation differs between pulse sequences in articular cartilage. J Magn Reson Imaging 42:105-13
Iagaru, Andrei; Mittra, Erik; Minamimoto, Ryogo et al. (2015) Simultaneous whole-body time-of-flight 18F-FDG PET/MRI: a pilot study comparing SUVmax with PET/CT and assessment of MR image quality. Clin Nucl Med 40:1-8
Riley, Geoffrey M; McWalter, Emily J; Stevens, Kathryn J et al. (2015) MRI of the hip for the evaluation of femoroacetabular impingement; past, present, and future. J Magn Reson Imaging 41:558-72

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