K24 Abstract The overall goals of this K24 application are to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinician investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a Mohs Surgeon in the Department of Dermatology at Massachusetts General Hospital and an Associate Professor in the Department of Population Medicine at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including an NCI-funded R01 of 80,000 Kaiser Permanente Health Plan members previously enrolled in a Research Program in Genes and Environmental Health; an ongoing NIAMS-funded R03 comparing the effectiveness of two commonly used topical agents in the treatment of precancerous skin lesions; and a foundation-funded project comprehensively characterizing acral lentiginous melanomas, a rare melanoma subtype. Dr. Asgari has already successfully served as a research mentor to numerous clinicians in training, and is continuing to mentor multiple individuals ranging from medical students to junior faculty in her new academic environment at Harvard Medical School. This K24 award would come at a critical time in Dr. Asgari's career, as she solidifies her independent research trajectory and seeks to increase her availability to mentor junior investigators. The award will also support a new research investigation that builds on Dr. Asgari's ongoing NIH supported work in cutaneous carcinogensis with a renewed focus on precancerous skin lesions (actinic keratoses). The proposed scientific aims will take advantage of existing data from Dr. Asgari's R01 and R03 awards with actinic keratoses as the outcome measure of interest. This project will allow mentees the ability to use existing datasets to examine novel topics in the risk factors and treatment variation of actinic keratoses.
This mid-career investigator award will support an outstanding program in patient-oriented research in dermatologic diseases at Massachusetts General Hospital and Harvard Medical School, expanding the applicant's research while supporting her mentoring of trainees. It will result in advances in the management of patients with skin diseases, especially those at high risk for skin cancer, through high quality patient-oriented research performed by well-trained clinical investigators.
|Blomberg, Maria; Rifas-Shiman, Sheryl L; Camargo Jr, Carlos A et al. (2017) Low Maternal Prenatal 25-Hydroxyvitamin D Blood Levels Are Associated with Childhood Atopic Dermatitis. J Invest Dermatol 137:1380-1384|
|Dobry, Allison S; Quesenberry, Charles P; Ray, G Thomas et al. (2017) Serious infections among a large cohort of subjects with systemically treated psoriasis. J Am Acad Dermatol 77:838-844|
|Levandoski, Katherine A; Nazarian, Rosalynn M; Asgari, Maryam M (2017) Hypertrophic lichen planus mimicking squamous cell carcinoma: The importance of clinicopathologic correlation. JAAD Case Rep 3:151-154|
|Nguyen, M O; Nguyen, H T; Asgari, M M (2017) Towards the use of precision medicine in predicting cutaneous squamous cell carcinoma risk among solid organ transplant recipients. Br J Dermatol 177:901-902|
|Storer, Molly; Zhu, Zheng; Sokil, Monika et al. (2017) Community-Based Practice Variations in Topical Treatment of Actinic Keratoses. JAMA Dermatol 153:468-470|
|Wehner, Mackenzie R; Levandoski, Katherine A; Kulldorff, Martin et al. (2017) Research Techniques Made Simple: An Introduction to Use and Analysis of Big Data in Dermatology. J Invest Dermatol 137:e153-e158|
|Gilkey, Melissa B; Mays, Darren; Asgari, Maryam M et al. (2017) Parental Support for Age-based Indoor Tanning Restrictions. Am J Prev Med 53:473-480|
|Neugebauer, Romain; Levandoski, Katherine A; Zhu, Zheng et al. (2017) A real-world, community-based cohort study comparing the effectiveness of topical fluoruracil vs. topical imiquimod for the treatment of actinic keratosis. J Am Acad Dermatol :|
|Yesantharao, Pooja; Wang, Wei; Ioannidis, Nilah M et al. (2017) Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol 78:327-335|
|Blomberg, M; He, S Y; Harwood, C et al. (2017) Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients. Br J Dermatol 177:1225-1233|