K24 Abstract The overall goals of this K24 application are to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinician investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a Mohs Surgeon in the Department of Dermatology at Massachusetts General Hospital and an Associate Professor in the Department of Population Medicine at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including an NCI-funded R01 of 80,000 Kaiser Permanente Health Plan members previously enrolled in a Research Program in Genes and Environmental Health; an ongoing NIAMS-funded R03 comparing the effectiveness of two commonly used topical agents in the treatment of precancerous skin lesions; and a foundation-funded project comprehensively characterizing acral lentiginous melanomas, a rare melanoma subtype. Dr. Asgari has already successfully served as a research mentor to numerous clinicians in training, and is continuing to mentor multiple individuals ranging from medical students to junior faculty in her new academic environment at Harvard Medical School. This K24 award would come at a critical time in Dr. Asgari's career, as she solidifies her independent research trajectory and seeks to increase her availability to mentor junior investigators. The award will also support a new research investigation that builds on Dr. Asgari's ongoing NIH supported work in cutaneous carcinogensis with a renewed focus on precancerous skin lesions (actinic keratoses). The proposed scientific aims will take advantage of existing data from Dr. Asgari's R01 and R03 awards with actinic keratoses as the outcome measure of interest. This project will allow mentees the ability to use existing datasets to examine novel topics in the risk factors and treatment variation of actinic keratoses.

Public Health Relevance

This mid-career investigator award will support an outstanding program in patient-oriented research in dermatologic diseases at Massachusetts General Hospital and Harvard Medical School, expanding the applicant's research while supporting her mentoring of trainees. It will result in advances in the management of patients with skin diseases, especially those at high risk for skin cancer, through high quality patient-oriented research performed by well-trained clinical investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR069760-02
Application #
9456662
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Tseng, Hung H
Project Start
2017-03-17
Project End
2022-02-28
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
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Dobry, Allison S; Quesenberry, Charles P; Ray, G Thomas et al. (2017) Serious infections among a large cohort of subjects with systemically treated psoriasis. J Am Acad Dermatol 77:838-844
Levandoski, Katherine A; Nazarian, Rosalynn M; Asgari, Maryam M (2017) Hypertrophic lichen planus mimicking squamous cell carcinoma: The importance of clinicopathologic correlation. JAAD Case Rep 3:151-154
Nguyen, M O; Nguyen, H T; Asgari, M M (2017) Towards the use of precision medicine in predicting cutaneous squamous cell carcinoma risk among solid organ transplant recipients. Br J Dermatol 177:901-902
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Gilkey, Melissa B; Mays, Darren; Asgari, Maryam M et al. (2017) Parental Support for Age-based Indoor Tanning Restrictions. Am J Prev Med 53:473-480
Neugebauer, Romain; Levandoski, Katherine A; Zhu, Zheng et al. (2017) A real-world, community-based cohort study comparing the effectiveness of topical fluoruracil vs. topical imiquimod for the treatment of actinic keratosis. J Am Acad Dermatol :
Yesantharao, Pooja; Wang, Wei; Ioannidis, Nilah M et al. (2017) Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system. Hum Immunol 78:327-335
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