The K24 Midcareer Investigator Award presents Dr. Chenchen Wang with an exciting opportunity to collaborate with renowned scientists at Tufts, Brown, Harvard, and Boston University Schools of Medicine to mentor new investigators who wish to contribute to patient-oriented research in Complementary and Alternative Medicine (CAM). Currently Dr. Wang is Associate Professor at Tufts University School of Medicine and Director of the Tufts Center for Complementary and Integrative Medicine, with a strong record of research, publication, and mentoring. She is the Principal Investigator of two NIH-funded R01 projects studying comparative-effectiveness and cost-effectiveness of mind-body interventions for osteoarthritis and fibromyalgia, as well as post-traumatic stress disorder in military populations Dr. Wang's long-term goal is to advance the science of mind-body medicine to promote health and healing. Her immediate goals are to obtain protected time to train the next generation of CAM scientists in patient- oriented research and to expand her innovative, multi-method, multidisciplinary clinical and translational research programs for chronic disabling conditions. Dr. Wang has an established track record of effectively mentoring trainees at various levels with diverse backgrounds, including clinicians from different countries and disciplines. Her CAM mentoring program, as well as her expertise on mind-body interventions, has been fully integrated into the research and teaching infrastructure of the Tufts Clinical and Translational Science Institute. Combined with outstanding resources and a long-recognized diverse training environment, these selected mentees will obtain training in rigorous scientific methodology, integrity, ethics, and grant applications necessary to stimulate high-quality, translational, patient-oriented research with a multidisciplinary team. Building upon NCCAM-funded R21 and R01 studies, the proposed research aims to:1) Evaluate comparative effectiveness and cost-effectiveness of mind-body interventions;2) Elucidate neurobiological mechanisms of CAM therapies;3) Investigate unmet needs of novel and cost-effective CAM treatments;4) Create comprehensive interdisciplinary approaches in CAM training;5) Develop the scientific and structural foundations for future R01 and other program applications;6) Extend opportunities to new scientists to integrate CAM into mainstream institutions and research settings. This K24 will therefore promote multidisciplinary patient-oriented research for the next generation of investigators in order to substantially advance the science on integrative medicine and the contributions to health, health care, and well-being for all.

Public Health Relevance

Complementary and integrative medicine approaches offer the potential to positively affect the progression of disease, while simultaneously diminishing pain and morbidity. This Midcareer Investigator Award will support the implementation of a multidisciplinary mentoring and research program for the next generation of CAM researchers. The program will substantially advance the science of mind-body medicine to contribute to cost- effective healthcare and the direction of future medicine.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1-PK (26))
Program Officer
Khalsa, Partap Singh
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
United States
Zip Code
Marszalek, Jolanta; Price, Lori Lyn; Harvey, William F et al. (2017) Outcome Expectations and Osteoarthritis: Association of Perceived Benefits of Exercise With Self-Efficacy and Depression. Arthritis Care Res (Hoboken) 69:491-498
Lee, Augustine C; Harvey, William F; Price, Lori Lyn et al. (2017) Mindfulness Is Associated With Treatment Response From Nonpharmacologic Exercise Interventions in Knee Osteoarthritis. Arch Phys Med Rehabil 98:2265-2273.e1
Lee, Augustine C; Harvey, William F; Wong, John B et al. (2017) Effects of Tai Chi versus Physical Therapy on Mindfulness in Knee Osteoarthritis. Mindfulness (N Y) 8:1195-1205
Lee, Augustine C; Driban, Jeffrey B; Price, Lori Lyn et al. (2017) Responsiveness and Minimally Important Differences for 4 Patient-Reported Outcomes Measurement Information System Short Forms: Physical Function, Pain Interference, Depression, and Anxiety in Knee Osteoarthritis. J Pain 18:1096-1110
Chen, Bo; Zhan, Hongsheng; Marszalek, Jolanta et al. (2016) Traditional Chinese Medications for Knee Osteoarthritis Pain: A Meta-Analysis of Randomized Controlled Trials. Am J Chin Med 44:677-703
Niles, Barbara L; Mori, DeAnna L; Polizzi, Craig P et al. (2016) Feasibility, qualitative findings and satisfaction of a brief Tai Chi mind-body programme for veterans with post-traumatic stress symptoms. BMJ Open 6:e012464
Reid, Kieran F; Fielding, Roger A; Price, Lori Lyn et al. (2016) Reply. Arthritis Rheumatol 68:1047-8
Wang, Chenchen; Schmid, Christopher H; Iversen, Maura D et al. (2016) Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial. Ann Intern Med 165:77-86
Driban, Jeffrey B; Morgan, Nani; Price, Lori Lyn et al. (2015) Patient-Reported Outcomes Measurement Information System (PROMIS) instruments among individuals with symptomatic knee osteoarthritis: a cross-sectional study of floor/ceiling effects and construct validity. BMC Musculoskelet Disord 16:253
Wang, Chenchen; McAlindon, Timothy; Fielding, Roger A et al. (2015) A novel comparative effectiveness study of Tai Chi versus aerobic exercise for fibromyalgia: study protocol for a randomized controlled trial. Trials 16:34

Showing the most recent 10 out of 17 publications