Patient-oriented translational research in complementary and integrative medicine (CIM) has an urgent need for developing a pipeline of qualified investigators given increased public interest in the use of CIM approaches and the limited evidence base for their efficacy for treatment and prevention of major disorders. The next generation of CIM researchers will benefit from the dedicated mentorship of experienced midcareer clinical investigators. Helen Lavretsky, M.D., M.S., a Professor of Psychiatry at UCLA, was named the Semel Scholar in Integrative Mental Health, and is a clinical investigator dedicated to patient-oriented research in integrative medicine and mental health. Dr. Lavretsky has a strong record of research, publication, teaching and mentoring. Her mentored K23 (2001-2007), and the first K-24 (2010-2015) career development grants from the NIMH, and several subsequent R01 research grants from the NIMH and NCCIH focused on developing combination and complementary treatment and prevention approaches for late-life mood and cognitive disorders. Dr. Lavretsky mentors junior faculty, graduate and post-doctoral students, resident physician, and medical students. Of the 22 trainees mentored during the first K24 award, 11 (50%) now have their own NIH grants or other career grants, and others are still engaged in clinical research and training. This proposed K24 Midcareer Investigator Award in Patient-Oriented Research will provide protected time and help expand Dr. Lavretsky's research and mentoring program in translational neuroscience of mind-body interventions, and to extend mentorship to junior CIM investigators. The main aims of this program will be: 1: Testing the health benefits of mind-body interventions; 2: Applying innovative technologies to test the neuroplastic and genomic mechanisms of action of integrative medicine therapies; and 3: Developing the pipeline of future researchers of CIM. Dr. Lavretsky is developing a curriculum for training of junior investigators in translational science of integrative medicine for the UCLA CTSI program, as well as a Graduate Degree course in positive neuroscience of integrative medicine, and plans to submit an application to NCCIH for a T-32 NRSA Institutional Research Training Grant in the next two years. These training grants will allow the development of a CIM-targeted research training program at the UCLA. Combined with existing resources and reputation of the UCLA CTSI and Collaborative Centers for Integrative Medicine, this would attract an increasing pool of the most qualified and promising future CIM researchers. The proposed research and additional training will build upon findings from previous research; especially the NCCIH-funded R-01 study of Tai Chi. The K-24 award proposed project will expand to the pilot studies of multimodal MRI to focus on 1) a pilot study of MRS/ DTI/ fMRI, and 2) gene expression predictors of response to Tai Chi. This K24 application aims to provide mentoring and a research environment to develop an exceptionally strong and diverse group of CIM researchers who will play leading roles in the future of integrative medicine research.

Public Health Relevance

This proposed K24 Midcareer Investigator Award in Patient-Oriented Research will help expand the Candidate's research and mentoring program in translational neuroscience of mind-body interventions. The main aims of this program will be: 1: Testing the health benefits of mind-body interventions; 2: Applying innovative technologies to test the neuroplastic and genomic mechanisms of action of integrative medicine therapies; and Aim 3: Developing the pipeline of future researchers of CIM. The research and training proposal is based on the NCCIH funded R-01, and additional pilot projects investigating neural and genomic biomarkers of response to mind-body interventions.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AT009198-03
Application #
9543964
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Belfer, Inna
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Eyre, Harris A; Siddarth, Prabha; Acevedo, Bianca et al. (2017) A randomized controlled trial of Kundalini yoga in mild cognitive impairment. Int Psychogeriatr 29:557-567
Eyre, Harris; Siddarth, Prabha; Cyr, Natalie et al. (2017) Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study. Pharmacopsychiatry 50:256-263
Eyre, Harris A; Lavretsky, Helen; Forbes, Malcolm et al. (2017) Convergence Science Arrives: How Does It Relate to Psychiatry? Acad Psychiatry 41:91-99
Lavretsky, Helen (2017) Hallucinations Predict Relapse After Discontinuation of Risperidone in Patients With Alzheimer's Disease and Psychosis or Agitation. Am J Psychiatry 174:307-308
Lavretsky, Helen (2016) Lifestyle Medicine for Prevention of Cognitive Decline: Focus on Green Tea. Am J Geriatr Psychiatry 24:890-2
Yang, Hongyu; Leaver, Amber M; Siddarth, Prabha et al. (2016) Neurochemical and Neuroanatomical Plasticity Following Memory Training and Yoga Interventions in Older Adults with Mild Cognitive Impairment. Front Aging Neurosci 8:277
Acevedo, Bianca P; Pospos, Sarah; Lavretsky, Helen (2016) The Neural Mechanisms of Meditative Practices: Novel Approaches for Healthy Aging. Curr Behav Neurosci Rep 3:328-339