I am committed to clinical research to advance the treatment of patients with hematologic malignancies. To accomplish this goal, a new generation of clinical investigators must be trained. My major obstacle to pursuing clinical research and training is time pressures from clinical and administrative obligations. This award would guarantee protected time for clinical research and mentoring. The studies proposed are reflective of my strong interest in Graft versus Host disease. Each study was developed with the fellow or junior faculty member. The studies reflect the spectrum of graft versus those disease including the use of non myeloablative preparative regimens for high risk donor transplants, treatment of steroid refractory Graft versus Host disease in a study examining the pharmacokinetics of Pentostatin, and a staging system for chronic graft versus host disease. Besides meeting weekly with the trainees, formal course work will be taken through the School of Hygiene and Public Health Masters in the Clinical Investigation program. I also plan to take some of the courses to complement my recently completed MBA. Formal evaluation of my effectiveness will be obtained to improve my mentoring skills and to monitor my clinical research productivity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24CA083804-02
Application #
6522511
Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
Project Start
2001-09-01
Project End
2006-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$144,583
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Akpek, Gorgun; Lee, Stephanie J; Flowers, Mary E et al. (2003) Performance of a new clinical grading system for chronic graft-versus-host disease: a multicenter study. Blood 102:802-9