My objective is to develop a clinical research program in transplantation that focuses on transplant immunology and transplant pharmacology/pharmacogenomics, and that prepares the next generation of clinical investigators in this area. Three projects are proposed, which together will require approximately 25% effort. Project 1 and 2 have federal funding project 3 will partially depend on funding obtained by this grant. Project 1: Minor Histocompatibility Vaccination After Allo-Transplant. (1R21 CA 101337-01, Quick trial, PI, Koen van Besien) Project 2: Busulfan conditioning: optimization, kinetics, genomics (1R21 CA115097-01, Quick trial, PI, Koen van Besien) Project 3: NKT cell biology and functions in the transplant setting. The three projects address complementary clinical questions in transplant and are not overlapping. Each have translational as well as clinical components and all projects maximally utilize the current research infrastructure and experience at University of Chicago. They provide excellent opportunities for mentees to design, conduct and interpret clinical and correlative studies. These projects are therefore well suited to prepare the next generation of researchers who will require the ability to integrate clinical and laboratory research. My mentoring efforts require approximately 25% effort. They will parallel the specific aims of this protocol and will center on positions for clinical research, lab research in pharmacology/pharmacogenomics and lab research in immunology. Several junior faculty are already being mentored. They include two clinical investigators and one pharmacologist. Plans for K23, K08 or dual PI R21 are outlined for each. I anticipate dual mentorship by myself and by another senior faculty with different expertise for each of these investigators. Throughout the course of the grant I will identify new potential investigators through the fellowship, residency and medical student program, where I have been very active in teaching and mentoring.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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University of Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
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van Besien, Koen; Hari, Parameswaran; Zhang, Mei-Jie et al. (2016) Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival. Haematologica 101:634-43
Tsai, Stephanie B; Liu, Hongtao; Shore, Tsiporah et al. (2016) Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning. Biol Blood Marrow Transplant 22:1065-1072
Petri, Camille R; O'Donnell, Peter H; Cao, Hongyuan et al. (2014) Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant. Leuk Lymphoma 55:2866-73
Van Besien, Koen; Liu, Hongtao; Jain, Nitin et al. (2013) Umbilical cord blood transplantation supported by third-party donor cells: rationale, results, and applications. Biol Blood Marrow Transplant 19:682-91
Dierickx, Daan; van Besien, Koen (2013) Therapeutic drug monitoring: a way to improve long-term immunological balance? Leuk Lymphoma 54:5-6
Jain, Nitin; Liu, Hongtao; Artz, Andrew S et al. (2013) Immune reconstitution after combined haploidentical and umbilical cord blood transplant. Leuk Lymphoma 54:1242-9
Muffly, Lori S; Boulukos, Melissa; Swanson, Kate et al. (2013) Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. Biol Blood Marrow Transplant 19:429-34
Villa, Carlos H; Shore, Tsiporah; Van Besien, Koen et al. (2012) Addition of plerixafor to mobilization regimens in autologous peripheral blood stem cell transplants does not affect the correlation of preharvest hematopoietic precursor cell enumeration with first-harvest CD34+ stem cell yield. Biol Blood Marrow Transplant 18:1867-75
van Besien, Koen; Stock, Wendy; Rich, Elizabeth et al. (2012) Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 18:913-21
Pai, Rish K; van Besien, Koen; Hart, John et al. (2012) Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. Leuk Lymphoma 53:1552-7

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