This Midcareer Investigator Award application seeks support to provide Dr. Freedland with protected time for patient-oriented research (POR) and to act as research mentor for junior faculty and 1 research fellow per year. Dr. Freedland's POR focuses on retrospective cohort studies with a transitioning emphasis on prospective clinical trials aimed at developing new and less toxic treatments to minimize prostate cancer treatment side effects and slow prostate cancer progression. Herein, he proposes a new trial comparing a carbohydrate-restricted diet vs. control for men with PSA recurrence after prostate cancer therapy aiming to slow the rate of PSA rise (lengthen the PSA doubling time), as an indirect measure of slowed prostate cancer growth. Secondary outcomes include weight loss and important prostate cancer biomarkers. Successful completion of this award will advance our understanding of lifestyle and other low toxicity interventions for prostate cancer as well as help educate the next generation of POR investigators.

Public Health Relevance

Prostate Cancer is a major public health burden. Despite great efforts, and some progress, today, prostate cancer remains the number two cancer killer of men and a significant source of morbidity. New and less toxic treatments aimed at both minimizing treatment side-effects and slowing disease progression at sorely needed. Moreover, a new generation of investigators focused on patient-oriented research (POR) is also needed. To these ends, this Midcareer Investigator Award application seeks support to provide Dr. Freedland with protected time for POR and to act as research mentor for junior faculty and 1 research fellow per year. While Dr. Freedland's POR focus to date has been largely on retrospective cohort studies, this award coincides with a shift in his POR toward prospective clinical trials aimed at developing new and less toxic treatments to minimize prostate cancer treatment side effects and slow prostate cancer progression. Moreover, Dr. Freedland is a proven successful mentor to junior investigators in training and this award allows him to continue to spend the time necessary to mentor and help train the next generation of POR investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24CA160653-02
Application #
8531887
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
2012-08-16
Project End
2017-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$175,476
Indirect Cost
$12,998
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Klaassen, Zachary; Singh, Abhay A; Howard, Lauren E et al. (2015) Is clinical stage T2c prostate cancer an intermediate- or high-risk disease? Cancer 121:1414-21
Vidal, Adriana C; Williams, Christina D; Allott, Emma H et al. (2015) Carbohydrate intake, glycemic index and prostate cancer risk. Prostate 75:430-9
Vidal, Adriana C; Howard, Lauren E; Moreira, Daniel M et al. (2015) Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study. Clin Cancer Res 21:756-62
McDonald, Alicia C; Vira, Manish A; Vidal, Adriana C et al. (2014) Association between systemic inflammatory markers and serum prostate-specific antigen in men without prostatic disease - the 2001-2008 National Health and Nutrition Examination Survey. Prostate 74:561-7
Allott, Emma H; Howard, Lauren E; Cooperberg, Matthew R et al. (2014) Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. BJU Int 114:661-6
Moreira, D M; Cooperberg, M R; Howard, L E et al. (2014) Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database. Prostate Cancer Prostatic Dis 17:91-6
Gaines, Alexis R; Turner, Elizabeth L; Moorman, Patricia G et al. (2014) The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort. Cancer Causes Control 25:1029-35
Ho, Tammy; Howard, Lauren E; Vidal, Adriana C et al. (2014) Smoking and risk of low- and high-grade prostate cancer: results from the REDUCE study. Clin Cancer Res 20:5331-8
Moreira, Daniel M; Aronson, William J; Terris, Martha K et al. (2014) Cigarette smoking is associated with an increased risk of biochemical disease recurrence, metastasis, castration-resistant prostate cancer, and mortality after radical prostatectomy: results from the SEARCH database. Cancer 120:197-204
Vidal, Adriana C; Howard, Lauren E; Moreira, Daniel M et al. (2014) Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study. Cancer Epidemiol Biomarkers Prev 23:2936-42

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