This is the resubmission of an application for a renewal of a Midcareer Investigator Award in Patient-Oriented Research (K24) in response to PA-08-151 focused in the areas of Child Psychiatry/Pediatric Psychopharmacology and the Addictive Disorders. The objectives of the applicant are to a) increase the candidate's knowledge in stimulant misuse and substance use disorders (SUD) in adolescents and young adults, b) further his involvement in training and mentoring in Child Psychiatry/Psychology and Addictions, and c) complete a five-year prospective study of the etiologies of stimulant misuse in college students. This Award would also provide the opportunity to expand a well-integrated Center for the diagnosis and treatment of adolescent SUD in Child Psychiatry at the Massachusetts General Hospital (MGH). Despite the well-documented safety of stimulants in the treatment of ADHD, it has largely been survey studies that have shown the extent of misuse (defined here as any use outside of medical indication) of stimulants in college-aged students. These studies indicate a clinical and public health concern and through this proposal the candidate would like to address and evaluate the etiological factors, context, and characteristics of misuse of stimulants in college students. Potential subjects will be screened using a brief Internet survey and those eligible will be asked to complete a direct interview. The data collected can elucidate important issues like do inherent vulnerabilities exist and manifest under certain contexts? This investigation will provide an excellent foundation for the applicant to further his knowledge. From multiple collaborative efforts, the candidate will develop specific skills related to the study of addictions and young adults with stimulant misuse and to continue his work on methodological and conceptual issues in the phenomenology and treatment of adolescents with SUD. Through didactic seminars, supervision, meetings, and involvement in the ongoing research, the applicant proposes to continue mentoring individuals at all levels. In this manner, the candidate will continue to satisfy career development and mentoring objectives of the K24 award while addressing the vexing issues of etiologies of stimulant misuse in college students.
By identifying and thoroughly examining this subject area, we will be better suited to dissect underlying characteristics and potential mechanisms related to the misuse of stimulants. Data derived from this proposed study will have important and directly applicable clinical and public health relevance.
|Wilens, Timothy E; Rosenbaum, Jerrold F (2013) Transitional aged youth: a new frontier in child and adolescent psychiatry. J Am Acad Child Adolesc Psychiatry 52:887-90|
|Wilens, Timothy E; Martelon, MaryKate; Anderson, Jesse P et al. (2013) Difficulties in emotional regulation and substance use disorders: a controlled family study of bipolar adolescents. Drug Alcohol Depend 132:114-21|
|Mick, Eric; McGough, James; Loo, Sandra et al. (2011) Genome-wide association study of the child behavior checklist dysregulation profile. J Am Acad Child Adolesc Psychiatry 50:807-17.e8|
|Wilens, Timothy E; Morrison, Nicholas R; Prince, Jefferson (2011) An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults. Expert Rev Neurother 11:1443-65|
|Wilens, Timothy E; Martelon, MaryKate; Fried, Ronna et al. (2011) Do executive function deficits predict later substance use disorders among adolescents and young adults? J Am Acad Child Adolesc Psychiatry 50:141-9|
|Hua, Liwei L; Wilens, Timothy E; Martelon, MaryKate et al. (2011) Psychosocial functioning, familiality, and psychiatric comorbidity in bipolar youth with and without psychotic features. J Clin Psychiatry 72:397-405|
|Wilens, Timothy E; Adler, Lenard A; Tanaka, Yoko et al. (2011) Correlates of alcohol use in adults with ADHD and comorbid alcohol use disorders: exploratory analysis of a placebo-controlled trial of atomoxetine. Curr Med Res Opin 27:2309-20|
|Wilens, Timothy E; Martelon, Marykate; Joshi, Gagan et al. (2011) Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHD. J Am Acad Child Adolesc Psychiatry 50:543-53|
|Wilens, Timothy E; Morrison, Nicholas R (2011) The intersection of attention-deficit/hyperactivity disorder and substance abuse. Curr Opin Psychiatry 24:280-5|
|Wilens, Timothy E; Gault, Laura M; Childress, Ann et al. (2011) Safety and efficacy of ABT-089 in pediatric attention-deficit/hyperactivity disorder: results from two randomized placebo-controlled clinical trials. J Am Acad Child Adolesc Psychiatry 50:73-84.e1|
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