MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH (K24) This K24 application seeks support that is essential for the candidate's continued career development as an independent, patient-oriented researcher and mentor. The candidate has attained considerable expertise in the clinical neurobiology of stimulant addiction, employing convergent methodologies (neuroimaging, psychopharmacology, drug self-administration, and most recently, genetics). He has demonstrated considerable productivity as evidenced by peer-reviewed publications (both as principal and senior author) and extramural research support (6 R01s, 1 R03, 2 research training grants, 2 center grant sections, scientific co-directorship of a major center, and 6 foundation grant awards). However, expiration of the candidate's K02 has resulted in him having to assume major (>50%) clinical and administrative responsibilities unrelated to this research. This occurs at a critical time, as this new area (genetics) requires highly specialized training and increasing reliance of trainees on this expertise. Thus, the K24 award is vital for sustaining the candidate's patient-oriented research and research-related mentoring activates. Moreover, the award will enable the candidate's immersion in an area of rapid change, thereby facilitating his mastery of newly independent research skills in substance dependence genetics. Justification for the award is provided by a comprehensive 5-year career development plan which 1) allows the candidate to enhance skills in the genetics / pharmacogenetics of complex traits, and 2) enables the candidate to continue his mentoring of beginning investigators in clinical research. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Two representative research studies are presented in detail - including 1) a study of drug dependence in an isolated population (active) and 2) a pharmacogenetic study of cocaine, disulfiram and genetic variation (C-1021T) in the gene for dopamine beta-hydroxylase (DBH).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA017899-04
Application #
8033210
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Gordon, Harold
Project Start
2007-08-01
Project End
2013-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
4
Fiscal Year
2011
Total Cost
$165,416
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Matuskey, David; Worhunksy, Patrick; Correa, Elizabeth et al. (2016) Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers. Neuroimage 130:241-7
Kober, Hedy; Lacadie, Cheryl M; Wexler, Bruce E et al. (2016) Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study. Neuropsychopharmacology 41:628-37
Matuskey, David; Gaiser, Edward C; Gallezot, Jean-Dominique et al. (2015) A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO. Drug Alcohol Depend 154:167-73
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Matuskey, David; Bhagwagar, Zubin; Planeta, Beata et al. (2014) Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biol Psychiatry 76:816-22
Matuskey, David; Gallezot, Jean-Dominique; Pittman, Brian et al. (2014) Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO. Drug Alcohol Depend 139:100-5
Natarajan, Annamalai; Gaiser, Edward; Angarita, Gustavo et al. (2014) Conditional Random Fields for Morphological Analysis of Wireless ECG Signals. ACM BCB 2014:370-379
Gallezot, Jean-Dominique; Zheng, Ming-Qiang; Lim, Keunpoong et al. (2014) Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner. J Nucl Med 55:960-6

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