The primary goals of this K24 competing renewal application are to enable Roger Weiss, M.D., to 1) continue to conduct and extend his patient-oriented research (POR) with drug dependent patients, particularly those with co-occurring disorders;and 2) provide intensive and high-quality mentorship to early-career investigators in POR. A K24 renewal will continue to give Dr. Weiss protected time for research and mentoring that would otherwise be spent on clinical and administrative duties. Dr. Weiss, Professor of Psychiatry at Harvard Medical School and Chief of the Division of Alcohol and Drug Abuse at McLean Hospital, Belmont, Massachusetts, has conducted POR since 1980, emphasizing studies that 1) integrate different treatment approaches, and 2) influence clinical practice. Since receiving a K24 award in September 2007, Dr. Weiss has accomplished the major goals of his original application. He has mentored 35 junior investigators, including 17 with K awards. He has authored 72 publications, including 34 publications with a mentee as first author. He successfully completed a randomized controlled trial of a """"""""community-friendly"""""""" version of Integrated Group Therapy that he developed for patients with bipolar disorder and substance dependence, and successfully led a multi-site study of prescription opioid dependence treatment in the NIDA Clinical Trials Network (CTN). Dr. Weiss'research plan for this renewal application includes continued work as a Node PI in the NIDA CTN, in which he is leading a long-term follow-up study of patients with prescription opioid dependence. He will also serve as Co-Investigator or consultant on several studies with mentees as PI. Further, he plans to submit proposals to 1) expand the scope of Integrated Group Therapy to include all mood disorders, and 2) study treatment approaches for pain clinic patients who misuse opioids. Dr. Weiss'mentoring plan includes training his mentees in 1) clinical aspects of drug abuse;2) designing and implementing drug abuse research studies;3) preparing scientific papers and presentations;4) writing successful grant applications;and 5) responsible conduct of research. He will accomplish this with a combination of individual and group meetings;collaborative mentoring;role modeling;and integrating mentoring with the Harvard Clinical and Translational Science Award (CTSA) Consortium. Dr. Weiss'career development plan involves learning more about treatment and clinical research with patients with severe pain and opioid dependence in a pain clinic;longitudinal data analytic strategies;and genetics. These activities will simultaneously enhance Dr. Weiss'research and his mentoring skills. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POR with this patient population.

Public Health Relevance

The primary goals of this K24 competing renewal application are to enable Roger Weiss, M.D., to 1) continue to conduct and extend his patient-oriented research with drug dependent patients, particularly those with co-occurring disorders;and 2) provide intensive and high-quality mentorship to early-career investigators in patient-oriented research. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduc research with this patient population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA022288-07
Application #
8490326
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Onken, Lisa
Project Start
2007-04-01
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
7
Fiscal Year
2013
Total Cost
$178,975
Indirect Cost
$13,257
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
McHugh, R Kathryn; Weiss, Roger D; Cornelius, Marise et al. (2016) Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain. J Pain 17:806-14
Hill, Kevin P; Weiss, Roger D (2016) Minimal Physical Health Risk Associated With Long-term Cannabis Use--But Buyer Beware. JAMA 315:2338-9
McHugh, R Kathryn; Fitzmaurice, Garrett M; Griffin, Margaret L et al. (2016) Association between a brief alcohol craving measure and drinking in the following week. Addiction 111:1004-10
Copersino, Marc L; Price, Jenessa S; Frost, Katherine H et al. (2016) Default Mode Network Functional Reorganization During Early Abstinence in Polysubstance-Using Emerging Adults Treated for Opioid Dependence. J Neuropsychiatry Clin Neurosci :appineuropsych15090240
McHugh, R Kathryn; Fulciniti, Francesca; Mashhoon, Yasmin et al. (2016) Cue-induced craving to paraphernalia and drug images in opioid dependence. Am J Addict 25:105-9
Griffin, Margaret L; McDermott, Katherine A; McHugh, R Kathryn et al. (2016) Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain. Drug Alcohol Depend 163:216-21
DeVido, Jeffrey; Bogunovic, Olivera; Weiss, Roger D (2015) Alcohol use disorders in pregnancy. Harv Rev Psychiatry 23:112-21
Hilario, E Yvette; Griffin, Margaret L; McHugh, R Kathryn et al. (2015) Denial of urinalysis-confirmed opioid use in prescription opioid dependence. J Subst Abuse Treat 48:85-90
McDermott, Katherine A; Griffin, Margaret L; Connery, Hilary S et al. (2015) Initial response as a predictor of 12-week buprenorphine-naloxone treatment response in a prescription opioid-dependent population. J Clin Psychiatry 76:189-94
Griffin, Margaret L; Bennett, Heather E; Fitzmaurice, Garrett M et al. (2015) Health-related quality of life among prescription opioid-dependent patients: Results from a multi-site study. Am J Addict 24:308-14

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