This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24DA023186-01
Application #
7249107
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Biswas, Jamie
Project Start
2007-06-01
Project End
2012-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
1
Fiscal Year
2007
Total Cost
$183,251
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Chen, Lian-Yu; Martins, Silvia S; Strain, Eric C et al. (2018) Sex and age differences in risk factors of marijuana involvement during adolescence. Addict Disord Their Treat 17:29-39
Tompkins, D Andrew; Huhn, Andrew S; Johnson, Patrick S et al. (2018) To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients. Addiction 113:67-79
Dunn, Kelly E; Finan, Patrick H; Andrew Tompkins, D et al. (2018) Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients. Addict Behav 76:8-14
Dunn, Kelly E; Harrison, Joseph A; Leoutsakos, Jeannie-Marie et al. (2017) Continuous Abstinence During Early Alcohol Treatment is Significantly Associated with Positive Treatment Outcomes, Independent of Duration of Abstinence. Alcohol Alcohol 52:72-79
Mauro, Pia M; Furr-Holden, C Debra; Strain, Eric C et al. (2016) Classifying substance use disorder treatment facilities with co-located mental health services: A latent class analysis approach. Drug Alcohol Depend 163:108-15
Tompkins, D Andrew; Johnson, Patrick S; Smith, Michael T et al. (2016) Temporal preference in individuals reporting chronic pain: discounting of delayed pain-related and monetary outcomes. Pain 157:1724-32
Chen, Lian-Yu; Crum, Rosa M; Strain, Eric C et al. (2016) Prescriptions, nonmedical use, and emergency department visits involving prescription stimulants. J Clin Psychiatry 77:e297-304
Kiluk, Brian D; Carroll, Kathleen M; Duhig, Amy et al. (2016) Measures of outcome for stimulant trials: ACTTION recommendations and research agenda. Drug Alcohol Depend 158:1-7
Antoine, Denis; Heffernan, Sean; Chaudhry, Amina et al. (2016) Age and gender considerations for technology-assisted delivery of therapy for substance use disorder treatment: A patient survey of access to electronic devices. Addict Disord Their Treat 15:149-156
Sweeney, Mary M; Rass, Olga; Johnson, Patrick S et al. (2016) Initial feasibility and validity of a prospective memory training program in a substance use treatment population. Exp Clin Psychopharmacol 24:390-399

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