This is an application for a K24 Mid-Career Investigator Award in Patient Oriented Research for Scott H. Kollins, Ph.D. Dr. Kollins is an established expert in the areas of Attention Deficit Hyperactivity Disorder (ADHD) and stimulant psychopharmacology. He has been involved with and published a number of studies on clinical trials with ADHD patients and has conducted seminal work on the abuse potential of stimulant drugs as they pertain to the treatment of ADHD. More recently, Dr. Kollins'work has begun to identify important mechanisms that underlie the relationship between ADHD and nicotine dependence. The purpose of this K24 application is three-fold: 1) to extend Dr. Kollins'established record of patient-oriented research with individuals with ADHD;2) to explore the genetic and neuropsychopharmacological basis of nicotine dependence in these individuals;and 3) to allow Dr. Kollins to develop more formal mentoring arrangements with post-doctoral trainees and junior faculty in the areas of ADHD and nicotine dependence. The career development plan for this application will extend the applicant's knowledge and skills in two key areas: 1) molecular genetics;and 2) functional brain neuroimaging. Dr. Kollins will leverage existing collaborative relationships at Duke University Medical Center to accomplish these aims. The research plan for this application will build on existing and pending projects to further understand the association between ADHD and nicotine dependence. These studies include: 1) an existing human laboratory study of the abuse liability of methylphenidate in adults with and without ADHD (R01DA017196);2) an existing candidate gene study of persistent ADHD (R01NS049067);and 3) an existing laboratory study of the effects of nicotine withdrawal in ADHD and non-ADHD smokers (R21DA020806). New research will also be conducted to study the effects of stimulant drugs on smoking behavior in patients with ADHD and to explore the genetic and functional brain correlates of these effects. This research is of considerable public health significance. ADHD affects millions of individuals in the US and patients with ADHD smoke cigarettes at a significantly higher rate than the general population. Given that smoking is the single largest preventable cause of death and disease, understanding more about the relationship between ADHD and smoking/nicotine dependence therefore has the potential to prevent or treat a major public health and mental health problem.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA023464-04
Application #
8116632
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lin, Yu
Project Start
2008-07-15
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
4
Fiscal Year
2011
Total Cost
$152,218
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Mitchell, John T; Weisner, Thomas S; Jensen, Peter S et al. (2017) How Substance Users With ADHD Perceive the Relationship Between Substance Use and Emotional Functioning. J Atten Disord :1087054716685842
Sweitzer, Maggie M; Kollins, Scott H; Kozink, Rachel V et al. (2017) ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge. Neuropsychopharmacology :
Schechter, Julia C; Kollins, Scott H (2017) Prenatal Smoke Exposure and ADHD: Advancing the Field. Pediatrics 139:
Schoenfelder, Erin N; Kollins, Scott H (2016) Topical Review: ADHD and Health-Risk Behaviors: Toward Prevention and Health Promotion. J Pediatr Psychol 41:735-40
Mitchell, John T; Sweitzer, Maggie M; Tunno, Angela M et al. (2016) ""I Use Weed for My ADHD"": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD. PLoS One 11:e0156614
Lunsford-Avery, Jessica R; Krystal, Andrew D; Kollins, Scott H (2016) Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev 50:159-174
Lee, Chien-Ti; Clark, Trenette T; Kollins, Scott H et al. (2015) Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: race and gender differences. Drug Alcohol Depend 148:180-7
Clark, Trenette T; Yang, Chongming; McClernon, F Joseph et al. (2015) Racial differences in parenting style typologies and heavy episodic drinking trajectories. Health Psychol 34:697-708
Mitchell, John T; Zylowska, Lidia; Kollins, Scott H (2015) Mindfulness Meditation Training for Attention-Deficit/Hyperactivity Disorder in Adulthood: Current Empirical Support, Treatment Overview, and Future Directions. Cogn Behav Pract 22:172-191
Kollins, Scott H; Schoenfelder, Erin N; English, Joseph S et al. (2015) An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. J Subst Abuse Treat 48:96-103

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