This is an application for a K24 Mid-Career Investigator Award in Patient Oriented Research for Scott H. Kollins, Ph.D. Dr. Kollins is an established expert in the areas of Attention Deficit Hyperactivity Disorder (ADHD) and stimulant psychopharmacology. He has been involved with and published a number of studies on clinical trials with ADHD patients and has conducted seminal work on the abuse potential of stimulant drugs as they pertain to the treatment of ADHD. More recently, Dr. Kollins'work has begun to identify important mechanisms that underlie the relationship between ADHD and nicotine dependence. The purpose of this K24 application is three-fold: 1) to extend Dr. Kollins'established record of patient-oriented research with individuals with ADHD;2) to explore the genetic and neuropsychopharmacological basis of nicotine dependence in these individuals;and 3) to allow Dr. Kollins to develop more formal mentoring arrangements with post-doctoral trainees and junior faculty in the areas of ADHD and nicotine dependence. The career development plan for this application will extend the applicant's knowledge and skills in two key areas: 1) molecular genetics;and 2) functional brain neuroimaging. Dr. Kollins will leverage existing collaborative relationships at Duke University Medical Center to accomplish these aims. The research plan for this application will build on existing and pending projects to further understand the association between ADHD and nicotine dependence. These studies include: 1) an existing human laboratory study of the abuse liability of methylphenidate in adults with and without ADHD (R01DA017196);2) an existing candidate gene study of persistent ADHD (R01NS049067);and 3) an existing laboratory study of the effects of nicotine withdrawal in ADHD and non-ADHD smokers (R21DA020806). New research will also be conducted to study the effects of stimulant drugs on smoking behavior in patients with ADHD and to explore the genetic and functional brain correlates of these effects. This research is of considerable public health significance. ADHD affects millions of individuals in the US and patients with ADHD smoke cigarettes at a significantly higher rate than the general population. Given that smoking is the single largest preventable cause of death and disease, understanding more about the relationship between ADHD and smoking/nicotine dependence therefore has the potential to prevent or treat a major public health and mental health problem.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA023464-05
Application #
8279473
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lin, Yu
Project Start
2008-07-15
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$156,258
Indirect Cost
$11,575
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Mitchell, John T; Sweitzer, Maggie M; Tunno, Angela M et al. (2016) ""I Use Weed for My ADHD"": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD. PLoS One 11:e0156614
Mitchell, John T; Zylowska, Lidia; Kollins, Scott H (2015) Mindfulness Meditation Training for Attention-Deficit/Hyperactivity Disorder in Adulthood: Current Empirical Support, Treatment Overview, and Future Directions. Cogn Behav Pract 22:172-191
Kollins, Scott H; Schoenfelder, Erin N; English, Joseph S et al. (2015) An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. J Subst Abuse Treat 48:96-103
Lee, Chien-Ti; Clark, Trenette T; Kollins, Scott H et al. (2015) Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: race and gender differences. Drug Alcohol Depend 148:180-7
Wigal, Sharon B; Greenhill, Laurence L; Nordbrock, Earl et al. (2014) A randomized placebo-controlled double-blind study evaluating the time course of response to methylphenidate hydrochloride extended-release capsules in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 24:562-9
Schoenfelder, Erin N; Faraone, Stephen V; Kollins, Scott H (2014) Stimulant treatment of ADHD and cigarette smoking: a meta-analysis. Pediatrics 133:1070-80
Smith, Taylor F; Anastopoulos, Arthur D; Garrett, Melanie E et al. (2014) Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. Am J Med Genet B Neuropsychiatr Genet 165B:691-704
Kollins, Scott H; Adcock, R Alison (2014) ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. Prog Neuropsychopharmacol Biol Psychiatry 52:70-8
Adjei, Akwete; Kupper, Robert J; Teuscher, Nathan S et al. (2014) Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers. Clin Drug Investig 34:795-805
Mitchell, John T; Dennis, Michelle F; English, Joseph S et al. (2014) Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder. Subst Use Misuse 49:1446-56

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