This application is a revised competing renewal for a K24 Mid-Career Scientist Award in Patient-Oriented Research. The original period of this award, which ends on June 30, 2014, focused broadly on understanding the mechanisms underlying elevated risk for cigarette smoking in individuals with ADHD, and specifically on neurobiological and genetic factors that may contribute to this risk. Consistent with the overall objectives of the K24 mechanism, the award aims emphasized the mentorship of junior investigators in patient-oriented research as it pertains to cigarette smoking. During the original project period, we were highly successful across the research, career development, and mentorship aims. As such, the overall goal of this competing renewal application is to extend our work on the common comorbidity between smoking/nicotine dependence in individuals with ADHD. In particular, we will apply the findings of our mechanistic work supported by the original project to the development of novel approaches to smoking cessation and prevention for this common and costly comorbidity. In particular, the scientific and career development goals of this application will be to characterize and evaluate the construct of motivation as it pertains to smoking in individuals with ADHD. Along with relevant faculty colleagues at Duke, Dr. Kollins will explore motivational processes from several different perspectives in smokers with and without ADHD. Consistent with the broad goals of the K24 mechanism, these aims will also provide a rich environment for the continued mentorship of junior investigators.

Public Health Relevance

Individual with Attention Deficit Hyperactivity Disorder (ADHD) is more likely to smoke cigarettes than the general population. They are also more likely to become regular smokers more quickly following initial use. Little is known about why individuals with ADHD are at increased risk for smoking or what the best ways to prevent or treat smoking might be. This proposed project will help develop more effective ways to prevent and treat smoking in individuals with ADHD and will also help train a new generation of investigators to study this important and costly problem.

National Institute of Health (NIH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Lin, Yu
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Duke University
Schools of Medicine
United States
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Kollins, Scott H; Schoenfelder, Erin N; English, Joseph S et al. (2015) An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. J Subst Abuse Treat 48:96-103
Mitchell, John T; Schick, Robert S; Hallyburton, Matt et al. (2014) Combined ecological momentary assessment and global positioning system tracking to assess smoking behavior: a proof of concept study. J Dual Diagn 10:19-29
Mitchell, John T; McIntyre, Elizabeth M; McClernon, F Joseph et al. (2014) Smoking motivation in adults with attention-deficit/hyperactivity disorder using the Wisconsin inventory of smoking dependence motives. Nicotine Tob Res 16:120-5
Kollins, Scott H; Adcock, R Alison (2014) ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. Prog Neuropsychopharmacol Biol Psychiatry 52:70-8
Kollins, Scott H; English, Joseph S; Itchon-Ramos, Nilda et al. (2014) A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD. J Atten Disord 18:158-68
Schoenfelder, Erin N; Faraone, Stephen V; Kollins, Scott H (2014) Stimulant treatment of ADHD and cigarette smoking: a meta-analysis. Pediatrics 133:1070-80
Mitchell, John T; Dennis, Michelle F; English, Joseph S et al. (2014) Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder. Subst Use Misuse 49:1446-56
Kollins, Scott H; Schoenfelder, Erin; English, Joseph S et al. (2013) Methylphenidate does not influence smoking-reinforced responding or attentional performance in adult smokers with and without attention deficit hyperactivity disorder (ADHD). Exp Clin Psychopharmacol 21:375-84
Kollins, Scott H; English, Joseph S; Roley, Michelle E et al. (2013) Effects of smoking abstinence on smoking-reinforced responding, withdrawal, and cognition in adults with and without attention deficit hyperactivity disorder. Psychopharmacology (Berl) 227:19-30
Fuemmeler, Bernard; Lee, Chien-Ti; Ranby, Krista W et al. (2013) Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample. Drug Alcohol Depend 132:301-8

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