This application for a mid-career investigator award seeks funds to support the PI's research career and mentoring activities. Funds from the award will allow the PI to expand his mentoring activities, develop additional skill sets in longitudinal data analysis and expand his program of research that involves understanding the etiology and longitudinal course of adolescent-onset substance use disorders. This award will result in relief from substantial administrative and clinical responsibilities as the Psychiatric Director of the Addiction, Research and Treatment Services (ARTS), a large treatment program affiliated with the University of Colorado Denver Anschutz Medical Campus. Effort will be redirected toward mentoring activities, career development, and research activities. The PI is currently involved in a number of studies that are examining adolescent and young adult substance use disorders, both from a clinical, behavior genetics, and molecular genetic perspective. The PI will expand his research program by expanding his current research projects to gather more information about adolescent perceptions and patterns of marijuana use in the light of the recent "medical marijuana" explosion as well as conduct a longitudinal study that will follow a sample of both clinical and community adolescents every 6 months for 3 years to examine the development of marijuana use patterns and associated HIV-risk behaviors.
Adolescent substance use disorders are a major national public health problem. The PI is a child and adolescent psychiatrist who studies the etiology and development of these serious conditions. He is a national resource in this area and will train additional new investigators in this critical area. He will expand his research program through this award to examine how the explosion in medical marijuana in Colorado is changing adolescent marijuana use patterns and how these changes interact with HIV-risk behaviors.
|Luk, Jeremy W; Worley, Matthew J; Winiger, Evan et al. (2016) Risky driving and sexual behaviors as developmental outcomes of co-occurring substance use and antisocial behavior. Drug Alcohol Depend 169:19-25|
|Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69|
|Bartels, Karsten; Binswanger, Ingrid A; Hopfer, Christian J (2016) Sources of Prescription Opioids for Nonmedical Use. J Addict Med 10:134|
|Choi, Tai Kiu; Worley, Matthew J; Trim, Ryan S et al. (2016) Effect of adolescent substance use and antisocial behavior on the development of early adulthood depression. Psychiatry Res 238:143-9|
|Kamens, Helen M; Corley, Robin P; Richmond, Phillip A et al. (2016) Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence. Behav Genet 46:693-704|
|Haberstick, Brett C; Boardman, Jason D; Wagner, Brandon et al. (2016) Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One 11:e0148373|
|Coors, Marilyn E; Raymond, Kristen M; McWilliams, Shannon K et al. (2015) What adolescents enrolled in genomic addiction research want to know about conflicts of interest. Drug Alcohol Depend 147:272-5|
|Coors, Marilyn E; Raymond, Kristen M; McWilliams, Shannon K et al. (2015) Adolescent perspectives on the return of individual results in genomic addiction research. Psychiatr Genet 25:127-30|
|Salomonsen-Sautel, Stacy; Min, Sung-Joon; Sakai, Joseph T et al. (2014) Trends in fatal motor vehicle crashes before and after marijuana commercialization in Colorado. Drug Alcohol Depend 140:137-44|
|Hopfer, Christian (2014) Implications of marijuana legalization for adolescent substance use. Subst Abus 35:331-5|
Showing the most recent 10 out of 11 publications