Drug abuse and addiction are devastating and chronic conditions that place a significant medical, financial, legal and social burden on our country. Interdisciplinary collaboration combined with technical advances has resulted in unprecedented opportunities to enhance addiction treatment efficacy and durability, and reduce vulnerability to addiction. Continued progress is vital to improving existing evidenced-based treatments and developing new treatments. It is therefore critical to attract and train clinical researchers in order to ensure that a diverse pool of highly skilled scientists will be available t address these urgent health care needs. Dr.
Aim ee McRae-Clark is a productive mid-career investigator who has maintained consistent NIH funding for her innovative work in the area of medications development and gender differences in addictions. In addition, she has a strong track-record of attracting and successfully mentoring medical, graduate and post-doctoral students as well as junior faculty in clinical research focused on substance use disorders. The objective of this Midcareer Investigator Award in Patient-Oriented Research is to provide support for protected time so that Dr. McRae-Clark can develop a more formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction. Particular emphasis will also be placed on increasing the participation of underrepresented minorities conducting patient-oriented research. In addition, she will build on her existing program of research by incorporating new proficiencies and research directions, including advanced biostatistical methods and exploration of the role the endogenous cannabinoid system plays in stress response. This award will enable her to increase the time she is able to devote to mentorship, to consolidate her training activities, and take her research activities in new and exciting directions.
The objective of this Midcareer Investigator Award in Patient-Oriented Research is to provide support for protected time so that Dr. Aimee McRae-Clark can develop a more formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction. Particular emphasis will also be placed on increasing the participation of underrepresented minorities conducting patient-oriented research.
|Baker, Nathaniel L; Gray, Kevin M; Sherman, Brian J et al. (2018) Biological correlates of self-reported new and continued abstinence in cannabis cessation treatment clinical trials. Drug Alcohol Depend 187:270-277|
|Bowen, Lynneice L; McRae-Clark, Aimee L (2018) Therapeutic Benefit of Smoked Cannabis in Randomized Placebo-Controlled Studies. Pharmacotherapy 38:80-85|
|Moran-Santa Maria, Megan M; Sherman, Brian J; Brady, Kathleen T et al. (2018) Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women. Pharmacol Biochem Behav 165:63-69|
|Tomko, Rachel L; Baker, Nathaniel L; McClure, Erin A et al. (2018) Incremental validity of estimated cannabis grams as a predictor of problems and cannabinoid biomarkers: Evidence from a clinical trial. Drug Alcohol Depend 182:1-7|
|Sherman, Brian J; Baker, Nathaniel L; Squeglia, Lindsay M et al. (2018) Approach bias modification for cannabis use disorder: A proof-of-principle study. J Subst Abuse Treat 87:16-22|
|Moreland, Angela D; McRae-Clark, Aimee (2018) Parenting outcomes of parenting interventions in integrated substance-use treatment programs: A systematic review. J Subst Abuse Treat 89:52-59|
|Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150|
|Sahlem, Gregory L; Tomko, Rachel L; Sherman, Brian J et al. (2018) Impact of cannabis legalization on treatment and research priorities for cannabis use disorder. Int Rev Psychiatry 30:216-225|
|Sahlem, Gregory L; Baker, Nathaniel L; George, Mark S et al. (2018) Repetitive transcranial magnetic stimulation (rTMS) administration to heavy cannabis users. Am J Drug Alcohol Abuse 44:47-55|
|Sherman, Brian J; Baker, Nathaniel L; McRae-Clark, Aimee L (2017) Effect of oxytocin pretreatment on cannabis outcomes in a brief motivational intervention. Psychiatry Res 249:318-320|
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