application) There is a National crisis in patient-oriented research (POR) in Nephrology. At the same time that Nephrology patient populations are increasing, fewer and fewer physicians are pursuing careers in POR, largely because of a lack of mentoring and nurturing by experienced investigators. The long-term goal of this project is to mentor young investigators to become independent clinical researchers in Nephrology. The major thrust of this effort is to improve outcomes in patients with chronic renal diseases. In this amended application, I describe my program in POR which will be conducted in a unique environment made possible by collaborative efforts between myself, the University of Texas Southwestern Medical Center at Dallas (UTSW) and the Dallas Nephrology Associates (DNA), an academically oriented private nephrology group. I have assembled resources from both institutions to produce a strong, integrated patient-oriented research program in Nephrology. The resources include the Nephrology Division and Campus of UTSW and its patient population and the research environment, patient population and computerized patient database at DNA (> 10,000 patients with renal diseases). The patient populations at UTSW and DNA include large numbers of African-Americans and Hispanics that have very high rates of type II diabetes and are at very high risk for end-stage renal disease. In addition, I have added children to all of the new research projects proposed in this amendment. Furthermore, to facilitate this program I will return to the full-time faculty of UTSW as Director of Patient-Oriented Research in Nephrology on July 1, 2000 indicating my commitment and the Institution's commitment to conduct of and training in POR. My mentoring program, aimed at postdoctoral fellows (100 annual applicants) and young faculty in Nephrology has four key components: 1) Direct involvement in mentored clinical research projects with experienced investigators; 2) Curriculum in techniques of patient-oriented research; 3) Didactic courses in POR; and 4) Literature reviews, practical training in data collection, hypothesis generation and testing, manuscript preparation and grant writing. Also, trainees and junior faculty, will be strongly encouraged to pursue an option to enroll in the Masters in Public Health program at UTSW. Since my original grant was submitted, I successfully recruited two Nephrology fellows into this program. This grant will greatly assist me in developing my program by providing resources for ongoing and new research as well as for mentoring the next generation of clinical researchers in Nephrology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK002818-05
Application #
6893315
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2001-05-01
Project End
2006-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
5
Fiscal Year
2005
Total Cost
$129,963
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451
Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671
Chen, Teresa K; Appel, Lawrence J; Grams, Morgan E et al. (2017) APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension). Arterioscler Thromb Vasc Biol 37:1765-1769
Juraschek, Stephen P; Appel, Lawrence J; Miller 3rd, Edgar R (2017) Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. Am J Hypertens 30:871-875
Chen, Teresa K; Tin, Adrienne; Peralta, Carmen A et al. (2017) APOL1 Risk Variants, Incident Proteinuria, and Subsequent eGFR Decline in Blacks with Hypertension-Attributed CKD. Clin J Am Soc Nephrol 12:1771-1777
Chen, Teresa K; Choi, Michael J; Kao, W H Linda et al. (2015) Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression. Clin J Am Soc Nephrol 10:2128-35
Chen, Teresa K; Estrella, Michelle M; Astor, Brad C et al. (2015) Longitudinal changes in hematocrit in hypertensive chronic kidney disease: results from the African-American Study of Kidney Disease and Hypertension (AASK). Nephrol Dial Transplant 30:1329-35
Chang, Alex; Greene, Tom H; Wang, Xuelei et al. (2015) The effects of weight change on glomerular filtration rate. Nephrol Dial Transplant 30:1870-7
Inrig, Jula K; Molina, Christopher; D'Silva, Kristin et al. (2015) Effect of low versus high dialysate sodium concentration on blood pressure and endothelial-derived vasoregulators during hemodialysis: a randomized crossover study. Am J Kidney Dis 65:464-73
Porter, Anna; Fischer, Michael J; Wang, Xuelei et al. (2014) Quality of life and outcomes in African Americans with CKD. J Am Soc Nephrol 25:1849-55

Showing the most recent 10 out of 55 publications