This application to renew my K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and teaching programs in pediatric inflammatory bowel disease (IBD) and pediatric nutrition at the University of California in San Francisco. Large cohorts of pediatric IBD patients are available at UCSF, augmented via collaborations with the Pediatric IBD Consortium in other IBD centers across the USA and within California. Ongoing IBD investigations include studies of the etiology of IBD utilizing the pediatric patient as a model for environmental exposures much less impacted by extraneous events compared with adults, the natural history of IBD beginning in childhood, particularly in those under six years of age, development of new strategies for treatment of pediatric IBD, and measurement of the quality of life in these subjects. Projects relating to pediatric nutrition focus on two main themes: assessing the influences of maternal nutrition knowledge and acculturation in Latino/Hispanic and Chinese-American children, taking advantage of the multi-ethnic demographics in the San Francisco Bay area to study development of eating behaviors and obesity in infants, young children and school age children. The influence of nutrition in various disease states is also under investigation. Trainees interested in pediatric gastroenterology and nutrition is encouraged to become directly involved in these clinical research training opportunities. The mentoring plan utilizes these projects to attract young investigators into the NIH-supported Research Training Program in Pediatric Gastroenterology and Nutrition (T32 DK 007762-28, PI Heyman). Structured mentoring is made available under my guidance, and trainees may enroll in coursework in the UCSF Masters in Clinical Research mentoring program that provides a well-designed environment for integration of epidemiological and biostatistical methodologies into clinical investigations. Additionally, trainees are provided with guidance and supervision by the Department of Pediatrics Scholarship Oversight Committee, which assures appropriate levels of mentoring and academic progress for the trainees. Trainees under my direct supervision are encouraged and assisted in designing and implementing research projects, analyzing resultant data, organizing oral/poster presentations, and preparing manuscripts for publication. In this enriched environment, trainees are stimulated to prepare for academic careers. The K24 award provides me with essential support for these educational and investigational efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK060617-10
Application #
8094241
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O3))
Program Officer
Podskalny, Judith M,
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$176,932
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Lowe, Margaret M; Mold, Jeff E; Kanwar, Bittoo et al. (2014) Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9:e87877
Verstraete, Sofia G; Heyman, Melvin B; Wojcicki, Janet M (2014) Breastfeeding offers protection against obesity in children of recently immigrated Latina women. J Community Health 39:480-6
Winter, Harland S; Krzeski, Piotr; Heyman, Melvin B et al. (2014) High- and low-dose oral delayed-release mesalamine in children with mild-to-moderately active ulcerative colitis. J Pediatr Gastroenterol Nutr 59:767-72
Salazar, Guadalupe; Heyman, Melvin B (2014) Benefits of attending a summer camp for children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 59:33-8
Salazar, Guadalupe; Barker, Judith C; Heyman, Melvin B (2013) Medical students' conceptualizations of quality of life associated with children with IBD. J Pediatr Gastroenterol Nutr 57:493-9
Wojcicki, Janet M; Geissler, Jillian D; Stokes, Christina W et al. (2013) The use of the RESPeRATE device to lower blood pressure in inner city obese adolescents and children: a pilot feasibility study. High Blood Press Cardiovasc Prev 20:89-92
Thaler, M Michael; Heyman, Melvin B (2013) Dedicated bibliometrics: a more appropriate impact factor for specialty journals? J Pediatr Gastroenterol Nutr 57:413
Zahir, N; Heyman, M B; Wojcicki, J M (2013) No association between childcare and obesity at age 4 in low-income Latino children. Pediatr Obes 8:e24-8
Courtier, Jesse; Ohliger, Michael; Rhee, Sue J et al. (2013) Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr 57:426-31
Watson, Lisa C; Kuchenbecker, Kristopher M; Schiller, Benjamin J et al. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol 20:876-83

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