This is an application for a Midcareer Investigator Award in Patient-Oriented Research (K24) for Improving the Effectiveness of Obesity Management. The award will provide the candidate 40% effort for each of the next 5 years to increase his mentoring of postdoctoral fellows and junior faculty and to continue his research to improve the treatment of obesity. Postdoctoral fellows will be provided both clinical and research training and will have the opportunity to collaborate on the candidate's current NIH-funded studies. These include two randomized clinical trials to improve the maintenance of weight loss. The first encourages obese individuals to increase their daily lifestyle activity (Lifestyle Activity for Weight Management, DK56114), while the second combines behavior modification with the long-term use of weight loss medication (Behavior Modification and Pharmacotherapy for Obesity, DK56124). A third trial is the Look AHEAD study that is assessing the long-term health consequences of intentional weight loss and increased physical activity in overweight individuals with type 2 diabetes (U01-DK57135). The candidate will assist postdoctoral fellows in initiating their own investigations and mentor them through the stages from formulating a suitable question to publishing their results. He will similarly facilitate the research of junior faculty who are supported by Mentored Patient-Oriented Research Awards (K23) and similar mechanisms. The present award will support the candidate's efforts to improve the treatment of obesity in primary care practice. Working with faculty in the Department of Family Practice and Community Medicine, he will develop a brief physician-delivered intervention for weight management. The success of this intervention will be assessed in a controlled pilot study conducted in the Department's outpatient practice. Thus, this award will help the candidate move beyond the customary efficacy trials of obesity therapies (conducted in research clinics such as his own) to examine the effectiveness of a weight management intervention delivered in the more challenging arena of primary care practice.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK065018-04
Application #
7107206
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2003-09-20
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
4
Fiscal Year
2006
Total Cost
$116,293
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Xanthopoulos, Melissa S; Moore, ReneƩ H; Wadden, Thomas A et al. (2013) The association between weight loss in caregivers and adolescents in a treatment trial of adolescents with obesity. J Pediatr Psychol 38:766-74

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