This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and mentoring programs at the Center for Motility and Functional Gastrointestinal Disorders at Children's Hospital in Boston. The primary goal for this award is to provide protected time for mentoring in the setting of several ongoing patient-oriented research projects in pediatric motility and related disorders. One of the main objectives is to provide research training and mentorship for young investigators in this field. There are three main projects that are proposed in this application. One focuses on the treatment of non-acid reflux with the use of baclofen, the other on the use of nitric oxide paste to treat obstructive symptoms in patients with a nom-relaxing [sic] internal anal sphincter, and the third is a translational project that's is part of a boarder focus on the relation between inflammation and motility problems. This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved in these clinical research training opportunities. Structured mentoring is made available under my guidance, and trainees will become proficient in the technical aspects of performing motility testing in children, the design and implementation of research projects, analysis of the data, organization for presentation, as well as manuscript preparation. Trainees may enroll in coursework at the Harvard School of Public Health or similar programs to learn advanced education in epidemiology, biostatistics, and clinical investigation. Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals.

Public Health Relevance

This award will provide support to mentor young investigators in the area of pediatric motility and related disorders. The studies proposed will improve the treatment of children with intractable reflux, intractable constipation or eosinophilic esophagitis. This award will also allow better training of young investigators in a field where new research is needed.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Podskalny, Judith M,
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Children's Hospital Boston
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Lexmond, Willem S; Neves, Joana F; Nurko, Samuel et al. (2014) Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol 109:646-57
Rodriguez, L; Roberts, L D; LaRosa, J et al. (2013) Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterol Motil 25:420-6, e299
Zimmerman, Lori A; Srinath, Arvind I; Goyal, Alka et al. (2013) The overlap of functional abdominal pain in pediatric Crohn's disease. Inflamm Bowel Dis 19:826-31
Lexmond, W S; Pardo, M; Rooney, K et al. (2013) Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy 43:902-13
Rodriguez, L; Nurko, S; Flores, A (2013) Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterol Motil 25:140-e81
Rodriguez, Leonel; Diaz, Juan; Nurko, Samuel (2013) Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children. J Pediatr 163:261-7
Chiou, Eric; Nurko, Samuel (2011) Functional abdominal pain and irritable bowel syndrome in children and adolescents. Therapy 8:315-331
Chiou, E; Rosen, R; Jiang, H et al. (2011) Diagnosis of supra-esophageal gastric reflux: correlation of oropharyngeal pH with esophageal impedance monitoring for gastro-esophageal reflux. Neurogastroenterol Motil 23:717-e326
Mousa, Hayat M; Rosen, Rachel; Woodley, Frederick W et al. (2011) [Esophageal impedance monitoring for gastroesophageal reflux]. Acta Gastroenterol Latinoam 41:146-61
Nurko, S; Scott, S M (2011) Coexistence of constipation and incontinence in children and adults. Best Pract Res Clin Gastroenterol 25:29-41

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