Chi-yuan Hsu, MD, MSc is applying for a Mid-career Investigator Award in Patient Oriented Research (K24) in order to augment his original research and mentorship efforts. The new research to be supported by this grant leverages Dr. Hsu's ongoing funded projects and represents thematic expansions of his prior work. It is also designed to provide training opportunities for mentees. The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts.
The specific aims are:
Aim 1 : To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this.
Aim 2 : To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD).
Aim 3 : To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury. Dr. Hsu has a strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Funding from this K24 award will permit Dr. Hsu to spend less time on administrative and clinical responsibilities and more time on research and mentoring.

Public Health Relevance

Acute deteriorations in kidney function are commonly encountered in clinical practice. But much remains unknown about the distribution of this disease entity on a population basis, its role in the transition from chronic to end-stage renal disease and the extent to which is it is associated with actual underlying kidney injury. The studies proposed by Dr. Hsu in this application will help advance knowledge and serve as a platform for rigorous training of young clinician-researchers committed to a career in kidney disease Patient-Oriented Research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZDK1-GRB-G (M2))
Program Officer
Rankin, Tracy L
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Hsu, Raymond K; Hsu, Chi-Yuan (2016) The Role of Acute Kidney Injury in Chronic Kidney Disease. Semin Nephrol 36:283-92
Bansal, Nisha; McCulloch, Charles E; Lin, Feng et al. (2016) Different components of blood pressure are associated with increased risk of atherosclerotic cardiovascular disease versus heart failure in advanced chronic kidney disease. Kidney Int 90:1348-1356
Ku, Elaine; McCulloch, Charles E; Mauer, Michael et al. (2016) Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. Diabetes Care 39:2218-2224
Ku, Elaine; Lipkowitz, Michael S; Appel, Lawrence J et al. (2016) Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int :
Hsu, Raymond K; Chai, Boyang; Roy, Jason A et al. (2016) Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 68:193-202
Hsu, Chi-Yuan; Hsu, Raymond K; Yang, Jingrong et al. (2016) Elevated BP after AKI. J Am Soc Nephrol 27:914-23
Hsu, Raymond K; McCulloch, Charles E; Heung, Michael et al. (2016) Exploring Potential Reasons for the Temporal Trend in Dialysis-Requiring AKI in the United States. Clin J Am Soc Nephrol 11:14-20
Ku, Elaine; Fine, Richard N; Hsu, Chi-Yuan et al. (2016) Height at First RRT and Mortality in Children. Clin J Am Soc Nephrol 11:832-9
Tuot, Delphine S; Zhu, Yunnuo; Velasquez, Alexandra et al. (2016) Variation in Patients' Awareness of CKD according to How They Are Asked. Clin J Am Soc Nephrol 11:1566-73
Ku, Elaine; Glidden, David V; Hsu, Chi-Yuan et al. (2016) Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD. J Am Soc Nephrol 27:551-8

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