Chi-yuan Hsu, MD, MSc is applying for a Mid-career Investigator Award in Patient Oriented Research (K24) in order to augment his original research and mentorship efforts. The new research to be supported by this grant leverages Dr. Hsu's ongoing funded projects and represents thematic expansions of his prior work. It is also designed to provide training opportunities for mentees. The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts.
The specific aims are:
Aim 1 : To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this.
Aim 2 : To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD).
Aim 3 : To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury. Dr. Hsu has a strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Funding from this K24 award will permit Dr. Hsu to spend less time on administrative and clinical responsibilities and more time on research and mentoring.

Public Health Relevance

Acute deteriorations in kidney function are commonly encountered in clinical practice. But much remains unknown about the distribution of this disease entity on a population basis, its role in the transition from chronic to end-stage renal disease and the extent to which is it is associated with actual underlying kidney injury. The studies proposed by Dr. Hsu in this application will help advance knowledge and serve as a platform for rigorous training of young clinician-researchers committed to a career in kidney disease Patient-Oriented Research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZDK1-GRB-G (M2))
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Rankin, Tracy L
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Sharief, Shimi; Hsu, Chi-Yuan (2017) The Transition From the Pre-ESRD to ESRD Phase of CKD: Much Remains to Be Learned. Am J Kidney Dis 69:8-10
Ku, Elaine; Kopple, Joel D; Johansen, Kirsten L et al. (2017) Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality. Am J Kidney Dis :
Lee, Benjamin J; Hsu, Chi-Yuan (2017) Acute kidney injury is important in the hospital and afterward. J Hosp Med 12:126-127
Ku, Elaine; Gassman, Jennifer; Appel, Lawrence J et al. (2017) BP Control and Long-Term Risk of ESRD and Mortality. J Am Soc Nephrol 28:671-677
Ku, Elaine; Bakris, George; Johansen, Kirsten L et al. (2017) Acute Declines in Renal Function during Intensive BP Lowering: Implications for Future ESRD Risk. J Am Soc Nephrol 28:2794-2801
Park, M; Katz, R; Shlipak, M G et al. (2017) Urinary Markers of Fibrosis and Risk of Cardiovascular Events and Death in Kidney Transplant Recipients: The FAVORIT Trial. Am J Transplant 17:2640-2649
Park, Meyeon; Hsu, Chi-Yuan; Go, Alan S et al. (2017) Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol 12:761-771
Carlos, Christopher A; McCulloch, Charles E; Hsu, Chi-Yuan et al. (2017) Colon Cancer Screening among Patients Receiving Dialysis in the United States: Are We Choosing Wisely? J Am Soc Nephrol 28:2521-2528
Ku, Elaine; Lipkowitz, Michael S; Appel, Lawrence J et al. (2017) Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int 91:443-450
Murphy, Daniel; McCulloch, Charles E; Lin, Feng et al. (2016) Trends in Prevalence of Chronic Kidney Disease in the United States. Ann Intern Med 165:473-481

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