This is a K-24 ('Mid-career investigator Award in Patient-Oriented Research') application by W. Ray Kim, MD entitled, """"""""Patient-Oriented and Effectiveness Research in Chronic Liver Disease."""""""" Chronic liver disease has a widespread health burden in the United States. It is the fourth most common cause of death in Americans aged between 41 and 50 years of age, indicating that it causes many premature deaths. Dr. Kim is one of the most productive researchers in patient-oriented research in liver disease. The most widely recognized achievement in Dr. Kim's research is the development, validation and refinement of the MELD score. He is also well known for his expertise in epidemiology, diagnosis, treatment and prevention of chronic viral hepatitis including hepatitis B and C. Since he joined the faculty at Mayo Clinic College of Medicine, he has led numerous research projects working with young investigators, many of whom continue their endeavors in academic medicine. He also organized educational programs in patient- oriented research methods on behalf of international academic societies. Dr. Kim's research program to date has been supported by three federal grants. The first grant continues to evaluate the MELD score and investigates chronic kidney disease in the setting of liver transplant candidates and recipients (R01). The second grant constitutes a pilot trial to test the hypothesis that nitric oxide plays an important role in post-transplant chronic kidney disease (R21). The third grant is a multicenter network to conduct research in hepatitis B (U01). In this application, Dr. Kim is requesting support of his time to mentor junior faculty members, fellows, residents and medical students working in patient oriented research. These mentees are mostly trainees at Mayo Clinic, but given the international background and reputation, selected individuals from institutions outside the US will also be included. Secondarily, the support will be used to enhance and supplement Dr. Kim's research expertise, specifically in the area of comparative effectiveness research and genetic epidemiology and bioinformatics. His mentoring plans include (1) formal methods training in patient-oriented research through the Center for Translational Science Activities (CTSA) and other didactic material at Mayo Clinic, (2) hands-on guidance for research experience in conducting individual projects, which includes study design, data collection and analysis, presentation and publication, and application for funding;and (3) one-on-one mentoring to accomplish career milestones in research from residency electives to fellowship training to junior faculty development. Strong Divisional and Institutional support exists to ensure the success of the mentoring program.

Public Health Relevance

Chronic liver disease is one of the most common causes of premature death in Ameri- cans. Dr. Kim has been one of the most productive researchers in patient-oriented re- search in chronic liver disease. In this application, Dr. Kim is requesting support of his time to mentor junior faculty members, fellows, residents and medical students working in patient oriented research. The grant will also enhance and supplement Dr. Kim's re- search expertise, specifically in the area of comparative effectiveness research and ge- netic epidemiology and bioinformatics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK092336-02
Application #
8471698
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2012-07-02
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$126,779
Indirect Cost
$9,391
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Wi, Chung-Il; Kim, W Ray; Gross, John B et al. (2016) Potential Efficacy of Pegylated Interferon-α and a Nucleos(t)ide Analogue as Combination Therapy for HBeAg-Positive Chronic Hepatitis B. Gut Liver 10:611-6
Udompap, Prowpanga; Mannalithara, Ajitha; Heo, Nae-Yun et al. (2016) Increasing prevalence of cirrhosis among U.S. adults aware or unaware of their chronic hepatitis C virus infection. J Hepatol 64:1027-32
Pham, Phuong-Thu T; Lunsford, Keri E; Bunnapradist, Suphamai et al. (2016) Simultaneous liver-kidney transplantation or liver transplantation alone for patients in need of liver transplantation with renal dysfunction. Curr Opin Organ Transplant 21:194-200
Ahn, J; Lee, H M; Lim, J K et al. (2016) Entecavir safety and effectiveness in a national cohort of treatment-naïve chronic hepatitis B patients in the US - the ENUMERATE study. Aliment Pharmacol Ther 43:134-44
Allen, Alina M; Kim, W Ray; Larson, Joseph J et al. (2016) The Epidemiology of Liver Diseases Unique to Pregnancy in a US Community: A Population-Based Study. Clin Gastroenterol Hepatol 14:287-94.e1-2
Lutchman, Glen; Kim, W Ray (2015) A glass half full: Implications of screening for hepatitis C virus in the era of highly effective antiviral therapy. Hepatology 61:1455-8
Nam, Byung-Ho; Park, Joong-Won; Jeong, Sook-Hyang et al. (2015) Korean Version of a Model to Estimate Survival in Ambulatory Patients with Hepatocellular Carcinoma (K-MESIAH). PLoS One 10:e0138374
Wi, Chung-Il; Loo, Nicole M; Larson, Joseph J et al. (2015) Low level of hepatitis B virus screening among patients receiving chemotherapy. Clin Gastroenterol Hepatol 13:970-5; quiz e51
Allen, Alina M; Kim, W Ray; Larson, Joseph J et al. (2015) Serum Cystatin C as an Indicator of Renal Function and Mortality in Liver Transplant Recipients. Transplantation 99:1431-5
Udompap, Prowpanga; Kim, Donghee; Kim, W Ray (2015) Current and Future Burden of Chronic Nonmalignant Liver Disease. Clin Gastroenterol Hepatol 13:2031-41

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