This is a new submission for a K24 mid-career investigator award in patient-oriented research to support the mentoring, research and career development activities of Dr. Scott Reeder. Dr. Reeder is an Associate Professor at the University of Wisconsin-Madison, with a primary appointment in Radiology and cross- appointments in the Departments of Medicine, Medical Physics, and Biomedical Engineering. After his arrival at UW-Madison in 2005, Dr. Reeder founded a patient-oriented research program for the development and translation of advanced MRI methods into clinical practice. He leads the UW Liver Imaging Research Program, an active NIDDK-funded group developing and validating advanced MRI methods for improved diagnosis of abdominal diseases. The group is focused on validation of quantitative MRI biomarkers of diffuse liver disease, including methods to quantify abdominal adiposity and liver fat, liver iron overload, and non-invasive methods to evaluate the hemodynamics of the liver in patients with portal hypertension. Dr. Reeder has played a major mentoring role at UW-Madison as the Director of the Clinical MRI fellowship for the past 8 years and in his new role as Associate Director of the UW MD/PhD program. He has mentored a large number of medical students, residents, clinical fellows, graduate students, post-doctoral fellows and visiting professors in a wide variety of patient-oriented imaging projects. Most of these projects are interdisciplinary in focus and Dr. Reeder has built well-established collaborations with Pediatric Endocrinology, Emergency Medicine, Hepatology, Hematology, and Transplant Surgery, among others. Dr. Reeder is also the Medical Director of MRI at UW. His combined clinical and research leadership roles have enabled him to build a thriving mentoring environment for patient- oriented imaging research. Support from a K24 award would provide Dr. Reeder with the dedicated time needed to mentor clinicians performing patient-oriented research by freeing him from clinical and administrative responsibilities. Dr. Reeder will also continue his NIDDK funded R01 projects and participate in responsible conduct of research activities. He will also pursue a career development plan that includes additional training in liver disease and metabolic syndrome, as well as patient-centered outcomes research. Finally, he will perform a community-based patient-oriented research project examining the role of quantitative MRI biomarkers in the evolution of ectopic abdominal fat and insulin resistance during puberty in school-age girls. This interdisciplinary study will be performed as part of an ongoing mentorship-collaboration with a junior investigator in Pediatric Endocrinology. Given the outstanding environment at UW-Madison and this well- established mentoring relationship, this project is expected to lay the groundwork for future proposals including a K23 career development award for Dr. Reeder's mentee in Pediatric Endocrinology and will provide exciting new scientific insight into insulin resistance and ectopic abdominal fat deposition during puberty.

Public Health Relevance

Obesity is increasingly common in children, and if not addressed can lead to long-term complications including diabetes, liver disease and premature vascular disease as young adults. Improved tools that are fast, inexpensive and accurate are needed to assess the changes in the body that occur in obesity. This K24 award will support the applicant to increase his available time and effort to mentor junior investigators and to conduct patient-oriented research, particularly in the area of childhood obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24DK102595-01
Application #
8750986
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2014-09-15
Project End
2019-08-31
Budget Start
2014-09-15
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$185,487
Indirect Cost
$13,740
Name
University of Wisconsin Madison
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Roldán-Alzate, Alejandro; Francois, Christopher J; Wieben, Oliver et al. (2016) Emerging Applications of Abdominal 4D Flow MRI. AJR Am J Roentgenol 207:58-66
Colgan, Timothy J; Hernando, Diego; Sharma, Samir D et al. (2016) The effects of concomitant gradients on chemical shift encoded MRI. Magn Reson Med :
Grayev, Allison; Reeder, Scott; Hanna, Amgad (2016) Use of chemical shift encoded magnetic resonance imaging (CSE-MRI) for high resolution fat-suppressed imaging of the brachial and lumbosacral plexuses. Eur J Radiol 85:1199-207
Bannas, Peter; Roldán-Alzate, Alejandro; Johnson, Kevin M et al. (2016) Longitudinal Monitoring of Hepatic Blood Flow before and after TIPS by Using 4D-Flow MR Imaging. Radiology 281:574-582
Nagle, Scott K; Schiebler, Mark L; Repplinger, Michael D et al. (2016) Contrast enhanced pulmonary magnetic resonance angiography for pulmonary embolism: Building a successful program. Eur J Radiol 85:553-63
Kinner, Sonja; Reeder, Scott B; Yokoo, Takeshi (2016) Quantitative Imaging Biomarkers of NAFLD. Dig Dis Sci 61:1337-47
Kasza, Ildiko; Hernando, Diego; Roldán-Alzate, Alejandro et al. (2016) Thermogenic profiling using magnetic resonance imaging of dermal and other adipose tissues. JCI Insight 1:e87146
Wang, Xiaoke; Hernando, Diego; Reeder, Scott B (2016) Sensitivity of chemical shift-encoded fat quantification to calibration of fat MR spectrum. Magn Reson Med 75:845-51
Mahlke, Christoph; Hernando, Diego; Jahn, Christina et al. (2016) Quantification of liver proton-density fat fraction in 7.1T preclinical MR systems: Impact of the fitting technique. J Magn Reson Imaging :
Hernando, Diego; Sharma, Samir D; Aliyari Ghasabeh, Mounes et al. (2016) Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med :

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