The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine;medical students;and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences. Public Health Relevance: This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.
This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.
|Miller, Kristin A; Spalt, Elizabeth W; Gassett, Amanda J et al. (2018) Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. J Expo Sci Environ Epidemiol :|
|Honda, Trenton; Eliot, Melissa N; Eaton, Charles B et al. (2017) Long-term exposure to residential ambient fine and coarse particulate matter and incident hypertension in post-menopausal women. Environ Int 105:79-85|
|Bell, Griffith; Mora, Samia; Greenland, Philip et al. (2017) Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 37:976-982|
|Kulick, Erin R; Wellenius, Gregory A; Kaufman, Joel D et al. (2017) Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). Stroke 48:1966-1968|
|D'Souza, Jennifer C; Kawut, Steven M; Elkayam, Laura R et al. (2017) Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect 125:077019|
|Sack, Coralynn; Vedal, Sverre; Sheppard, Lianne et al. (2017) Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study. Eur Respir J 50:|
|Gepner, Adam D; Young, Rebekah; Delaney, Joseph A et al. (2017) Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 6:|
|Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:341-8|
|Weuve, Jennifer; Kaufman, Joel D; Szpiro, Adam A et al. (2016) Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults. Environ Health Perspect 124:1000-8|
|Bergen, Silas; Sheppard, Lianne; Kaufman, Joel D et al. (2016) Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. J R Stat Soc Ser C Appl Stat 65:731-753|
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