Since completing my clinical training in 1989, my research career has been devoted to clinical ophthalmic research that has used a variety of epidemiologic methodologies to study therapeutic interventions, assess new technologies, and better understand mechanisms of disease. To a large extent, by productivity can be attributed to mentorship I received early in my career and the accessibility of skilled colleagues with multidisciplinary skills at the Johns Hopkins Schools of Medicine and Hygiene and Public Health. My clinical and administrative responsibilities have increased annually. The K24 can provide an ideal mechanism to allow me to continue to prioritize patient-oriented clinical research and mentorship. My 5-year plans include 1) the completion and dissemination of results of a large clinical trial on the value of medical testing for cataract surgery; 2) the conduct of a large prospective study on the progression and risk factors for posterior capsular opacification, using a digital system we have designed; 3) studying patient function and preferences related to refractive error and its correction using a questionnaire we have developed and validated; 4) initiating clinical trials comparing alternative treatments for dry eye; and 5) developing new methodologies to facilitate the postmarket surveillance of new ophthalmic technologies to assess safety. Effective mentorship of junior physicians will be achieved by incorporating them into the above research plans; acting as a liaison for them to related programs in the Schools of Medicine and Hygiene and Public Health; conducting the Public Health Ophthalmology fellowship; securing departmental and other pilot funds to initiate junior faculty clinical research and providing assistance with grant application. Both a firm commitment and additional linked support have been pledged by the Chairman of my department and the Deans' offices of the Johns Hopkins Schools of Medicine and Hygiene and Public Health.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24EY000395-04
Application #
6525002
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Redford, Maryann
Project Start
1999-09-30
Project End
2004-09-29
Budget Start
2002-09-30
Budget End
2003-09-29
Support Year
4
Fiscal Year
2002
Total Cost
$114,193
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Friedman, D S; Reeves, S W; Bass, E B et al. (2004) Patient preferences for anaesthesia management during cataract surgery. Br J Ophthalmol 88:333-5
Freeman, Ellen E; Munoz, Beatriz; Schein, Oliver D et al. (2004) Incidence and progression of lens opacities: effect of hormone replacement therapy and reproductive factors. Epidemiology 15:451-7
Akpek, Esen Karamursel; Dart, John K; Watson, Stephanie et al. (2004) A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. Ophthalmology 111:476-82
Reeves, Sherman W; Tielsch, James M; Katz, Joanne et al. (2003) A self-administered health questionnaire for the preoperative risk stratification of patients undergoing cataract surgery. Am J Ophthalmol 135:599-606
Vitale, Susan; Schein, Oliver D (2003) Qualitative research in functional vision. Int Ophthalmol Clin 43:17-30
Freeman, Ellen E; Munoz, Beatriz; West, Sheila K et al. (2003) Is there an association between cataract surgery and age-related macular degeneration? Data from three population-based studies. Am J Ophthalmol 135:849-56
Schein, Oliver D (2003) Assessing the safety of the new 30-night contact lenses. Eye Contact Lens 29:S157-9; discussion S166, S192-4
Congdon, N G; Schein, O D; von Kulajta, P et al. (2001) Corneal complications associated with topical ophthalmic use of nonsteroidal antiinflammatory drugs. J Cataract Refract Surg 27:622-31
Friedman, D S; Bass, E B; Lubomski, L H et al. (2001) The methodologic quality of clinical trials on regional anesthesia for cataract surgery. Ophthalmology 108:530-41
Schein, O D; Vitale, S; Cassard, S D et al. (2001) Patient outcomes of refractive surgery. The refractive status and vision profile. J Cataract Refract Surg 27:665-73

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