Description): The objectives of this proposal are to continue and expand the principal investigator's patient- oriented research in the area of walking (gait), and to expand her role as research mentor for physical medicine and rehabilitation (PM&R) resident physicians. The goals of the on-going and planned patient-oriented research are to (1) advance gait analysis using computer simulation techniques, (2) define and validate clinically relevant quantitative gait assessment measures, and (3) evaluate the effects of certain interventions on clinically relevant quantitative gait assessment measures. Specific studies will be accomplished in the Center for Rehabilitation Science which combines state-of-the-art quantitative gait measurement technology with advanced computer modeling and simulation capabilities. Each of the ongoing and planned studies enhances the ability to evaluate and improve gait performance and/or improve or prevent secondary disease and impairment. While these studies are specific in nature, they coordinate with each other to evaluate the complex relationships between impairment, functional limitation, and gait disability. Moreover, the specific projects allow distinct opportunities for highly clinically relevant research for PM&R resident and junior attending physicians. The mentoring plan includes (1) developing an integrated research didactic block into the current curriculum, (2) holding scheduled meetings between the principal investigator and resident physicians pursuing research projects, and (3) formalizing mechanisms to nurture a requirement for PM&R resident physicians to develop and complete a research project during residency. This proposal is expected to allow the principal investigator to continue and expand her patient-oriented gait research in an environment that supports and enhances her position as a role model in research, encouraging beginning clinicians in PM&R to pursue academic careers in patient-oriented rehabilitation research.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HD001351-06
Application #
6708050
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Nitkin, Ralph M
Project Start
2000-03-18
Project End
2005-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
6
Fiscal Year
2004
Total Cost
$114,266
Indirect Cost
Name
University of Virginia
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kerrigan, D Casey; Johansson, Jennifer L; Bryant, Mary G et al. (2005) Moderate-heeled shoes and knee joint torques relevant to the development and progression of knee osteoarthritis. Arch Phys Med Rehabil 86:871-5
Lee, Laura W; Zavarei, Keyvan; Evans, Jonathan et al. (2005) Reduced hip extension in the elderly: dynamic or postural? Arch Phys Med Rehabil 86:1851-4
Clancy, Edward A; Cairns, Kevin D; Riley, Patrick O et al. (2004) Effects of treadmill walking speed on lateral gastrocnemius muscle firing. Am J Phys Med Rehabil 83:507-14
Nolan, Lee; Kerrigan, D Casey (2003) Keep on your toes: gait initiation from toe-standing. J Biomech 36:393-401
Lelas, Jennifer L; Merriman, Gregory J; Riley, Patrick O et al. (2003) Predicting peak kinematic and kinetic parameters from gait speed. Gait Posture 17:106-12
Laughton, Carrie A; Slavin, Mary; Katdare, Kunal et al. (2003) Aging, muscle activity, and balance control: physiologic changes associated with balance impairment. Gait Posture 18:101-8
Kerrigan, D Casey; Xenopoulos-Oddsson, Annette; Sullivan, Meaghan J et al. (2003) Effect of a hip flexor-stretching program on gait in the elderly. Arch Phys Med Rehabil 84:1-6
Smith, Lynnelle K; Lelas, Jennifer L; Kerrigan, D Casey (2002) Gender differences in pelvic motions and center of mass displacement during walking: stereotypes quantified. J Womens Health Gend Based Med 11:453-8
Riley, P O; Kerrigan, D C (2001) The effect of voluntary toe-walking on body propulsion. Clin Biomech (Bristol, Avon) 16:681-7
Della Croce, U; Riley, P O; Lelas, J L et al. (2001) A refined view of the determinants of gait. Gait Posture 14:79-84

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