Diseases of the gastrointestinal tract cause significant morbidity and mortality among children. In developing countries, episodes of infectious diarrhea, including those associated with HIV/AIDS, are major causes of death. In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition. This revised application requests a mid-career investigator award in patient-oriented research (K24) for Christopher Duggan, MD, MPH. Dr. Duggan's overall research goal is to improve clinical outcomes in diarrheal diseases. He has a record of high productivity in funded research in the fields of nutrition, gastroenterology, and international health. Dr. Duggan has a sound track record of mentoring and excellent opportunities to work with junior investigators. He is Director of Clinical Research in the Division of Gastroenterology and Nutrition at Children's Hospital, Boston (CHB), a faculty member of the CHB Clinical Research Program, a member of the NIH-supported Harvard Digestive Diseases Research Center, and Associate Professor of Pediatrics at Harvard Medical School and of Nutrition at the Harvard School of Public Health. Trainees who are supported by two T32 training programs are available as mentees. The proposed research in this K24 award extends Dr. Duggan's ongoing studies, including an NICHD-supported R01 grant that seeks to evaluate the efficacy of micronutrient supplementation in Tanzanian children at risk of diarrhea. He and colleagues will conduct a randomized clinical trial: 1. To determine whether zinc or micronutrient supplementation has an enteropathogen species-specific effect in preventing gastrointestinal infections in Tanzanian children;and 2. To determine whether routine zinc supplementation reduces measures of iron status in Tanzanian children, compared to micronutrient supplements without zinc. This application offers a combination of a highly successful researcher in a supportive and intellectually rich environment. This mid-career investigator award is needed to protect Dr. Duggan's time to mentor beginning investigators in patient-oriented nutrition research and to expand his research in diarrheal diseases.)

Public Health Relevance

Diarrheal diseases are an important world-wide cause of childhood mortality and morbidity. This application for a K24 career development award will evaluate whether zinc supplementation has a species-specific effect in reducing the incidence of diarrhea in Tanzanian children, and will support the mentoring capacity of the applicant to foster the career of young investigators in the areas of nutrition, diarrhea, and global health.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Raiten, Daniel J
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Children's Hospital Boston
United States
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Ezeamama, A E; Duggan, C; Manji, K P et al. (2014) Clinical malaria diagnosis in pregnancy in relation to early perinatal mother-to-child transmission of HIV: a prospective cohort study. HIV Med 15:276-85
Lukose, Ammu; Ramthal, Asha; Thomas, Tinku et al. (2014) Nutritional factors associated with antenatal depressive symptoms in the early stage of pregnancy among urban South Indian women. Matern Child Health J 18:161-70
Coffin, Susan E; Klieger, Sarah B; Duggan, Christopher et al. (2014) Central line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections. Infect Control Hosp Epidemiol 35:1391-9
Mehta, Nilesh M; Raphael, Bram; Guteirrez, Ivan M et al. (2014) Comparison of body composition assessment methods in pediatric intestinal failure. J Pediatr Gastroenterol Nutr 59:99-105
Duggan, Christopher; Srinivasan, Krishnamachari; Thomas, Tinku et al. (2014) Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr 144:758-64
Hamilton, Susan; McAleer, Diane M; Ariagno, Katelyn et al. (2014) A stepwise enteral nutrition algorithm for critically ill children helps achieve nutrient delivery goals*. Pediatr Crit Care Med 15:583-9
Gosselin, Kerri B; Duggan, Christopher (2014) Enteral nutrition in the management of pediatric intestinal failure. J Pediatr 165:1085-90
Manji, Karim P; McDonald, Christine M; Kupka, Roland et al. (2014) Effect of multivitamin supplementation on the neurodevelopment of HIV-exposed Tanzanian infants: a randomized, double-blind, placebo-controlled clinical trial. J Trop Pediatr 60:279-86
Gosselin, Kerri B; Feldman, Henry A; Sonis, Andrew L et al. (2014) Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children. J Pediatr Gastroenterol Nutr 58:709-14
McGrath, Eric J; Thomas, Ron; Duggan, Christopher et al. (2014) Pentavalent rotavirus vaccine in infants with surgical gastrointestinal disease. J Pediatr Gastroenterol Nutr 59:44-8

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