Ttie Specific Aims of this application for a Midcareer Investigator Award in Patient-Oriented Research are 1) to use innovative technologies to Improve measurement of functional outcomes and to deliver psychological interventions to youth with chronic pain, and 2) to provide the candidate protected time and resources necessary to mentor postdoctoral fellows and junior faculty members who are pursuing clinical Investigation in pediatric pain. The candidate's programmatic research has focused on developing innovative methods to assess and treat chronic pain, disability, and sleep problems. During the course of this award, the candidate will complete research studies using innovative technologies to improve measurement of pain and sleep in a novel longitudinal study of sleep-wake behaviors. She will develop new research to examine the efficacy of an internet family cognitive-behavioral intervention on improving functional outcomes in adolescents with chronic pain. The candidate has an established track record of providing mentorship to graduate students, postdoctoral fellows, and junior faculty in psychology and medicine. The increased time allotted by this award will give the candidate the opportunity to focus on training additional postdoctoral fellows and faculty. The Research Plan includes two projects: an NIH/NICHD ROl "Sleep-wake disturbances in adolescents with chronic pain," and a new clinical trial of an internet delivered psychological treatment for chronic pain "Effect of Web-based CBT on Objective Functional Outcomes in Youth with Chronic Pain." The Mentoring Plan for beginning clinical Investigators consists of supervised participation in the candidate's ongoing research; conduct of independent research;and experience in professional activities and achieving professional milestones. A formal didactic program is available to mentees through the Human Investigations Program at Oregon Health &Science University (OHSU), a NIH K30 program, with seminars on study design, randomized controlled trials, ethics/human subjects, grant writing, and advanced analytic approaches. OHSU provides an ideal setting for this award because of the established collaborations, commitment to patient-oriented research, and the presence of a strong Clinical Translational Research Center.

Public Health Relevance

The public health goals of the candidate's research program are to develop innovative treatments for youth with chronic pain and sleep problems that can improve the current standard of care and minimize long-term problems with pain and disability. In addition, the candidate seeks to train the next generation of patient-oriented researchers in this area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HD060068-05
Application #
8307516
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Haverkos, Lynne
Project Start
2009-09-30
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
5
Fiscal Year
2012
Total Cost
$143,580
Indirect Cost
$10,636
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105
Noel, Melanie; Wilson, Anna C; Holley, Amy Lewandowski et al. (2016) Posttraumatic stress disorder symptoms in youth with vs without chronic pain. Pain 157:2277-84
Palermo, Tonya M; Law, Emily F; Fales, Jessica et al. (2016) Internet-delivered cognitive-behavioral treatment for adolescents with chronic pain and their parents: a randomized controlled multicenter trial. Pain 157:174-85
Noel, Melanie; Beals-Erickson, Sarah E; Law, Emily F et al. (2016) Characterizing the Pain Narratives of Parents of Youth With Chronic Pain. Clin J Pain 32:849-58
Groenewald, Cornelius B; Rabbitts, Jennifer A; Gebert, J Thomas et al. (2016) Trends in opioid prescriptions among children and adolescents in the United States: a nationally representative study from 1996 to 2012. Pain 157:1021-7
Noel, Melanie; Alberts, Nicole; Langer, Shelby L et al. (2016) The Sensitivity to Change and Responsiveness of the Adult Responses to Children's Symptoms in Children and Adolescents With Chronic Pain. J Pediatr Psychol 41:350-62
Palermo, Tonya M; Law, Emily F; Bromberg, Maggie et al. (2016) Problem-solving skills training for parents of children with chronic pain: a pilot randomized controlled trial. Pain 157:1213-23
Rabbitts, Jennifer A; Holley, Amy Lewandowski; Groenewald, Cornelius B et al. (2016) Association Between Widespread Pain Scores and Functional Impairment and Health-Related Quality of Life in Clinical Samples of Children. J Pain 17:678-84
Noel, Melanie; Groenewald, Cornelius B; Beals-Erickson, Sarah E et al. (2016) Chronic pain in adolescence and internalizing mental health disorders: a nationally representative study. Pain 157:1333-8
Law, Emily F; Fales, Jessica L; Beals-Erickson, Sarah E et al. (2016) A Single-Arm Feasibility Trial of Problem-Solving Skills Training for Parents of Children with Idiopathic Chronic Pain Conditions Receiving Intensive Pain Rehabilitation. J Pediatr Psychol :
Groenewald, Cornelius; Palermo, Tonya (2016) Legitimate opioid prescription increases the risk for future opioid misuse in some adolescents. Evid Based Nurs 19:83

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