This is a competitive renewal of K24HD060068. An estimated 20% to 40% of otherwise healthy children and adolescents suffer from chronic pain such as abdominal and musculoskeletal pain. Many of these children also experience significant sleep disturbances. Chronic pain and associated symptoms (such as sleep problems) results in a measurable decline in children's quality of life and produces stress and economic burden on parents and families. Increasingly, cognitive-behavioral therapies (CBT) are emerging as effective interventions for pediatric chronic pain. Because children and families face challenges accessing specialty services such as CBT for chronic pain, innovative technologies may be a solution for broadening access to care. The candidate's research activities during the prior period of K24 support focused on three areas: sleep-wake disturbances, behavioral interventions, and assessment of physical activity and function. Significant progress and achievements were made during the prior period of support in publications, new grants awarded, mentorship of fellows and junior faculty, career advancement, and academic leadership. The primary objectives of this renewal application for a Midcareer Investigator Award in Patient-Oriented Research are for the candidate to fully develop and evaluate innovative, cost-effective psychological treatments to decrease pain and sleep disturbances, and improve functioning in children and adolescents with chronic pain;to expand research knowledge of psychophysical pain assessment;and to teach new clinicians the skills necessary for developing innovative research in pediatric pain and supporting them in their transition to research independence. Over the next period of K24 support, the candidate will complete studies funded with current research support including a NIH/NICHD R01 grant to evaluate the efficacy of an internet-delivered behavioral intervention for pediatric chronic pain and disability (Project 1);and a NIH/NICHD R21 grant to develop and test the efficacy of a parental problem solving intervention designed to reduce distress in parent caregivers of youth with chronic pain (Project 2). New research proposed during the award is focused on evaluating the feasibility and preliminary efficacy of CBT for insomnia in youth with chronic pain and sleep disturbances (Project 3). Career objectives in mentoring beginning clinician investigators are to provide training in conducting assessment and intervention research using innovative technologies, to provide direct experience and training in writing grants and obtaining independent research funding, and to foster a career-long commitment to patient-oriented research. Formal didactic programs are available through several university programs including T32 postdoctoral training, a NIH KL2 program, and a Clinical research mentored scholars program. The University of Washington provides an ideal environment with a strong record of interdisciplinary patient-oriented pain research and collaborative science.

Public Health Relevance

Children and adolescents report severe chronic pain as frequently as adults, making chronic pain a major pediatric health issue with widespread social and economic costs. Unfortunately, access to effective evidence- based pain treatment is a significant barrier for many children. The candidate's research program is focused on developing innovative treatments for youth with chronic pain that are broadly accessible through the Internet, and which can target specific symptoms such as sleep problems. This research is expected to improve the current standard of care for children with chronic pain. The candidate seeks to train the next generation of patient-oriented researchers in this area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24HD060068-07
Application #
8634406
Study Section
Developmental Biology Subcommittee (CHHD)
Program Officer
Haverkos, Lynne
Project Start
2008-12-01
Project End
2019-06-30
Budget Start
2014-08-01
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98121
Rosenbloom, Brittany N; Rabbitts, Jennifer A; Palermo, Tonya M (2017) A developmental perspective on the impact of chronic pain in late adolescence and early adulthood: implications for assessment and intervention. Pain 158:1629-1632
Lifland, Brooke E; Mangione-Smith, Rita; Palermo, Tonya M et al. (2017) Agreement between Parent Proxy- and Child Self-Report of Pain Intensity and Health-Related Quality of Life after Surgery. Acad Pediatr :
Rabbitts, Jennifer A; Aaron, Rachel V; Fisher, Emma et al. (2017) Long-Term Pain and Recovery After Major Pediatric Surgery: A Qualitative Study With Teens, Parents, and Perioperative Care Providers. J Pain 18:778-786
Rabbitts, Jennifer A; Zhou, Chuan; Narayanan, Arthi et al. (2017) Longitudinal and Temporal Associations Between Daily Pain and Sleep Patterns After Major Pediatric Surgery. J Pain 18:656-663
Groenewald, Cornelius B; Beals-Erickson, Sarah E; Ralston-Wilson, Jaime et al. (2017) Complementary and Alternative Medicine Use by Children With Pain in the United States. Acad Pediatr 17:785-793
Rabbitts, Jennifer A; Fisher, Emma; Rosenbloom, Brittany N et al. (2017) Prevalence and Predictors of Chronic Postsurgical Pain in Children: A Systematic Review and Meta-Analysis. J Pain 18:605-614
Palermo, Tonya M; Dudeney, Joanne; Santanelli, James P et al. (2017) Feasibility and Acceptability of Internet-delivered Cognitive Behavioral Therapy for Chronic Pain in Adolescents With Sickle Cell Disease and Their Parents. J Pediatr Hematol Oncol :
Lewandowski Holley, Amy; Wilson, Anna C; Cho, Elise et al. (2017) Clinical Phenotyping of Youth With New-Onset Musculoskeletal Pain: A Controlled Cohort Study. Clin J Pain 33:28-36
Rabbitts, Jennifer A; Aaron, Rachel V; Zempsky, William T et al. (2017) Validation of the Youth Acute Pain Functional Ability Questionnaire in Children and Adolescents Undergoing Inpatient Surgery. J Pain 18:1209-1215
Livingstone, Margaret J; Groenewald, Cornelius B; Rabbitts, Jennifer A et al. (2017) Codeine use among children in the United States: a nationally representative study from 1996 to 2013. Paediatr Anaesth 27:19-27

Showing the most recent 10 out of 79 publications