This midcareer investigator award (K24) will provide protected time, resources, and structure that will allow for a progression in my research career trajectory, from a primary focus on HIV prevention, to a more inclusive and extensive conceptualization of prevention in the broader context of sexual and reproductive health (SRH). Further, it will allow me to engage in a comprehensive process of mentorship in the use of mixed methodologies in patient-oriented research. My career development goals are to: 1) expand my knowledge and expertise from HIV prevention alone to a more inclusive focus on sexual and reproductive health, 2) advance an expanded research agenda into the development of effective sexual and reproductive health technologies and interventions, and 3) advance my scholarly role in the use of mixed methods research for health promotion sciences by mentoring fellows and junior investigators in patient oriented research. The proposed mentorship plan will allow me to dedicate the necessary time and effort to fully integrate a comprehensive mixed methods research training program into my mentoring of junior investigators. The proposed research will provide the context for mentoring those investigators. The structured mentorship program will allow me to provide scientific leadership and in-depth methodological training for junior investigators interested in prevention intervention and treatment evaluation research. Through this mentorship in state-of-the-science mixed methods, I will promote the conduct of rigorous health promotion research across a wide range of health promotion sciences. My midcareer development plan will allow me to pursue learning and research activities that broaden my knowledge base and expertise into SRH and help me to better understand user experiences with SRH technologies, and identify those factors that impact use. Critical to use is """"""""acceptability."""""""" However, current conceptualizations of adherence and acceptability fail to fully articulate and account for patterns of use and non-use. I propose that a new model of use, """"""""Effective Use,"""""""" is required, and propose the conduct of a longitudinal prospective mixed methods study to articulate this model. The concept of """"""""Effective Use"""""""" begins with an inherent demand for the best user experience. It holds that a user's positive experience drives use, and that because use is maintained by this positive experience, higher exposure to the biomedical intervention (e.g., active ingredient), whether for prevention or treatment, is achieved. Relevance to Public Health: Sexual and reproductive health is a global public health priority. Providing efficacious SRH technologies that have the greatest likelihood of use will have the greatest impact on women's health. If successful, an Effective Use model would offer a new paradigm for the development of sexual and reproductive health technologies for women and their partners that will result in increased use and improved sexual and reproductive health outcomes.

Public Health Relevance

This K24 award will provide me with protected time to conduct mixed methods research that will articulate a new paradigm for the development of sexual and reproductive health technologies: specific to my research, our ability to develop technologies that have the greatest likelihood of use will have the greatest impact on women's sexual and reproductive health, a global public health priority. The K24 award will also allow time to implement a comprehensive mixed methods mentorship program to train a new cadre of researchers in the health promotion sciences

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Developmental Biology Subcommittee (CHHD)
Program Officer
Newcomer, Susan
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Miriam Hospital
United States
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Underhill, Kristen; Morrow, Kathleen M; Colleran, Christopher et al. (2016) Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men. AIDS Behav 20:1514-26
Vargas, Sara E; Fava, Joseph L; Severy, Lawrence et al. (2016) Psychometric Properties and Validity of a Multi-dimensional Risk Perception Scale Developed in the Context of a Microbicide Acceptability Study. Arch Sex Behav 45:415-28
Choo, Esther K; Tapé, Chantal; Glerum, Kimberly M et al. (2016) ""That's Where the Arguments Come in"": A Qualitative Analysis of Booster Sessions Following a Brief Intervention for Drug Use and Intimate Partner Violence in the Emergency Department. Subst Abuse 10:77-87
Kuo, Caroline; Atujuna, Millicent; Mathews, Catherine et al. (2016) Developing family interventions for adolescent HIV prevention in South Africa. AIDS Care 28 Suppl 1:106-10
Choo, Esther K; Garro, Aris C; Ranney, Megan L et al. (2015) Qualitative Research in Emergency Care Part I: Research Principles and Common Applications. Acad Emerg Med 22:1096-102
Ranney, Megan L; Meisel, Zachary F; Choo, Esther K et al. (2015) Interview-based Qualitative Research in Emergency Care Part II: Data Collection, Analysis and Results Reporting. Acad Emerg Med 22:1103-12
Morrow Guthrie, Kate; Vargas, Sara; Shaw, Julia G et al. (2015) The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development. PLoS One 10:e0145642
Rosen, Rochelle K; van den Berg, Jacob J; Vargas, Sara E et al. (2015) Meaning-making matters in product design: users' sensory perceptions and experience evaluations of long-acting vaginal gels and intravaginal rings. Contraception 92:596-601
Underhill, Kristen; Morrow, Kathleen M; Colleran, Christopher et al. (2015) A Qualitative Study of Medical Mistrust, Perceived Discrimination, and Risk Behavior Disclosure to Clinicians by U.S. Male Sex Workers and Other Men Who Have Sex with Men: Implications for Biomedical HIV Prevention. J Urban Health 92:667-86
Choo, Esther; Ranney, Megan; Wetle, Terrie et al. (2015) Attitudes Toward Computer Interventions for Partner Abuse and Drug Use Among Women in the Emergency Department. Addict Disord Their Treat 14:95-104

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